STRUCTURE-BASED DESIGN OF PROTACS FOR THE DEGRADATION OF SOLUBLE EPOXIDE HYDROLASE
Julia Schönfeld, Steffen Brunst, Ludmila Ciomirtan, Lena Willmer, Michel André Chromik, Adarsh M. Kumar, Timo Frömel, Nick Liebisch, Arne Hackspacher, Johanna H. M. Ehrler, Lukas Wintermeier, Christina Hesse, Jan Fiedler, Jan Heering, Hinrich Freitag, , Kerstin Hiesinger
This paper designs and tests sEH-PROTACs to degrade soluble epoxide hydrolase, identifying PROTAC 23 as effective in degrading sEH in human macrophages.
Journal of Medicinal Chemistry · Jun 18, 2025Peer-reviewedBiochemistry