Author

Steffen Brunst

Goethe University Frankfurt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

Ewgenij ProschakiD· 3 shared Aimo KanntiD· 2 shared Ingrid FlemingiD· 2 shared Julia Schönfeld· 2 shared Kerstin HiesingeriD· 2 shared Lilia WeizeliD· 2 shared Nick Liebisch· 2 shared Stefan KnappiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersPhysiology

Ewgenij ProschakORCID

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Author profile →

3 papers

Recent·Most cited

The transaminase-omega-amidase pathway is a redox switch in glutamine metabolism that generates alpha-ketoglutarate

Niklas Herrle, Pedro Felipe Malacarne, Timothy Warwick, Alfredo Cabrera‐Orefice, Yiheng Chen, Maedeh Gheisari, Souradeep Chatterjee, Matthias S. Leisegang, Tamim Sarakpi, Sarah Wionski, Melina Lopez, Carine Kader, Tom Teichmann, Maria-Kyriaki Drekolia, Ina Koch, , Flávia Rezende

The paper identifies the transaminase-omega-amidase pathway as a redox-sensitive metabolic switch in endothelial glutamine metabolism, showing that NIT2 oxidation inhibits its activity and affects angiogenesis.

The EMBO Journal · Dec 17, 2025Peer-reviewedPhysiology

STRUCTURE-BASED DESIGN OF PROTACS FOR THE DEGRADATION OF SOLUBLE EPOXIDE HYDROLASE

Julia Schönfeld, Steffen Brunst, Ludmila Ciomirtan, Lena Willmer, Michel André Chromik, Adarsh M. Kumar, Timo Frömel, Nick Liebisch, Arne Hackspacher, Johanna H. M. Ehrler, Lukas Wintermeier, Christina Hesse, Jan Fiedler, Jan Heering, Hinrich Freitag, , Kerstin Hiesinger

This paper designs and tests sEH-PROTACs to degrade soluble epoxide hydrolase, identifying PROTAC 23 as effective in degrading sEH in human macrophages.

Journal of Medicinal Chemistry · Jun 18, 2025Peer-reviewedBiochemistry

Click Chemistry Enables Rapid Development of Potent sEH PROTACs Using a Direct-to-Biology Approach

Julia Schönfeld, Nick Liebisch, Steffen Brunst, Lilia Weizel, Stefan Knapp, Aimo Kannt, Ewgenij Proschak, Kerstin Hiesinger

This paper develops a miniaturized Direct-to-Biology platform for rapid PROTAC degrader synthesis and screening, identifying potent sEH degraders with subnanomolar activity.

Chemical Communications · Jan 1, 2025Peer-reviewedCell Biology