Author

Nick Liebisch

Goethe University Frankfurt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Approach:deep learning· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Ewgenij ProschakiD· 3 shared Julia Schönfeld· 3 shared Kerstin HiesingeriD· 3 shared Stefan KnappiD· 3 shared Aimo KanntiD· 2 shared Lilia WeizeliD· 2 shared Steffen Brunst· 2 shared Adarsh M. KumariD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersBiochemistry

Ewgenij ProschakORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Click. Screen. Degrade. A Miniaturized D2B Workflow for rapid PROTAC Discovery

M. Mitrovic, Francesco Greco, Yiliam Cruz-Garcia, Aleksandar Lučić, Lasse Hoffmann, Rohit Chander, Julia Schönfeld, Nick Liebisch, Saran Aswathaman Sivashanmugam, Martin P. Schwalm, Markus Egner, Max Lewandowski, Daniel Merk, Viktoria Morasch, Elmar Wolf, , Stefan Knapp

This paper introduces a miniaturized PROTAC synthesis workflow that bypasses compound purification, enabling rapid screening and degradation assessment of multiple targets.

Journal of Medicinal Chemistry · Jan 23, 2026Peer-reviewedBiochemistry

STRUCTURE-BASED DESIGN OF PROTACS FOR THE DEGRADATION OF SOLUBLE EPOXIDE HYDROLASE

Julia Schönfeld, Steffen Brunst, Ludmila Ciomirtan, Lena Willmer, Michel André Chromik, Adarsh M. Kumar, Timo Frömel, Nick Liebisch, Arne Hackspacher, Johanna H. M. Ehrler, Lukas Wintermeier, Christina Hesse, Jan Fiedler, Jan Heering, Hinrich Freitag, , Kerstin Hiesinger

This paper designs and tests sEH-PROTACs to degrade soluble epoxide hydrolase, identifying PROTAC 23 as effective in degrading sEH in human macrophages.

Journal of Medicinal Chemistry · Jun 18, 2025Peer-reviewedBiochemistry

Click Chemistry Enables Rapid Development of Potent sEH PROTACs Using a Direct-to-Biology Approach

Julia Schönfeld, Nick Liebisch, Steffen Brunst, Lilia Weizel, Stefan Knapp, Aimo Kannt, Ewgenij Proschak, Kerstin Hiesinger

This paper develops a miniaturized Direct-to-Biology platform for rapid PROTAC degrader synthesis and screening, identifying potent sEH degraders with subnanomolar activity.

Chemical Communications · Jan 1, 2025Peer-reviewedCell Biology