Author

Jan Fiedler

Fraunhofer Institute for Toxicology and Experimental MedicineORCID 0000-0002-8855-2883Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Adarsh M. KumariD· 1 shared Aimo KanntiD· 1 shared Andreas PichiD· 1 shared Angelika Pfanne· 1 shared Annette Just· 1 shared Arne Hackspacher· 1 shared Arne SchmidtiD· 1 shared Astrid Brüggerhoff· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Adarsh M. KumarORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Medicinal ChemistryPeer-reviewedJun 18, 2025

STRUCTURE-BASED DESIGN OF PROTACS FOR THE DEGRADATION OF SOLUBLE EPOXIDE HYDROLASE

Julia Schönfeld, Steffen Brunst, Ludmila Ciomirtan…·Kerstin Hiesinger

This paper designs and tests sEH-PROTACs to degrade soluble epoxide hydrolase, identifying PROTAC 23 as effective in degrading sEH in human macrophages.

11 citations

humanprotein structure

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Pharmacology & ToxicologyScientific ReportsPeer-reviewedJul 16, 2024

SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation

Kevin Schmidt, Arne Schmidt, Sonja Groß…·Thomas Thum

This study shows SGLT2 inhibitors reduce endothelial to mesenchymal transition and cardiac fibroblast activation through effects on mitochondrial respiration, actin cytoskeleton, and specific transporters.

29 citationstop 2%

humanproteomics

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