Author

Atefeh Kianian

University of Bergen

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Neuroscience· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Anbin CheniD· 1 shared Cecilie Katrin KristianseniD· 1 shared Charalampos TzoulisiD· 1 shared Gareth J. SullivaniD· 1 shared Jessica FurrioliD· 1 shared Kristina Xiao LiangiD· 1 shared Laurence Albert BindoffiD· 1 shared Lena Elise HøylandiD· 1 shared

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1 shared paperNeuroscience

Anbin ChenORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintDec 20, 2020

Stem cell derived astrocytes with POLG mutations and mitochondrial dysfunction including abnormal NAD+ metabolism is toxic for neurons

Kristina Xiao Liang, Atefeh Kianian, Anbin Chen…·Laurence Albert Bindoff

This study shows that POLG mutations in astrocytes cause mitochondrial dysfunction and neurotoxicity, leading to neuronal death through altered metabolism and reactive astrocyte behavior.

4 citations

humanbulk RNA-seq

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