Evolutionary BiologybioRxiv
Sequence amplification via cell passaging creates spurious signals of positive adaptation in influenza H3N2 hemagglutinin
Claire McWhite, Austin Meyer, Claus O Wilke
This study shows that passaging influenza H3N2 isolates in cell culture introduces spurious adaptation signals in hemagglutinin sequences, which can mislead evolutionary analyses.
DOI 10.1093/ve/vew026