Cell BiologybioRxivPreprint
Constricted cell migration causes nuclear lamina damage, DNA breaks, and squeeze-out of repair factors
Jerome Irianto, Charlotte R. Pfeifer, Yuntao Xia…·Dennis E. Discher
The paper shows that constricted cell migration in stiff tissues causes nuclear lamina damage, DNA breaks, and loss of repair factors, leading to genomic instability.
DOI 10.1101/035626