Charlotte R. Pfeifer

The paper monitors live cell fluorescence to quantify aneuploidy-inducing perturbations in lung cancer and iPS cells, revealing increased chromosome mis-segregation and rare fluorescent-null cells.

The paper shows that constricted migration causes nuclear rupture and DNA damage, which are linked to cell cycle repression and DNA repair defects in cancer cells.

The paper shows that constricted cell migration in stiff tissues causes nuclear lamina damage, DNA breaks, and loss of repair factors, leading to genomic instability.