Cancer BiologyFEBS JournalPeer-reviewed
Inhibition of Lactate Dehydrogenase A (LDH-A) by Diclofenac Sodium Induces Apoptosis in HeLa Cells by Activation of AMPK
Avirup Malla, Suvroma Gupta, Runa Sur
This study shows that diclofenac inhibits LDH-A in HeLa cells, leading to ATP depletion, AMPK activation, and apoptosis via disruption of glycolytic metabolism.
11 citations