Cancer BiologybioRxivPreprint
A Three-Axis Framework for Therapy Prioritization in MBD4-Deficient Tumors: De-confounded Synthetic Lethality Modeling, Replication-Stress Pharmacology, and PARP1 Trapping Decoupling
Fahad Kiani, Ayesha Kiani, Rahima Nayeem
This paper identifies three therapeutic axes for MBD4-deficient tumors using a multi-layered framework, showing sensitivity to ATR inhibitors and cytidine analogs but not PARP inhibitors.
DOI 10.64898/2026.11.10.765519