PhysiologybioRxiv
Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart
A. Guevara, C. E. R. Smith, J. L. Caldwell…·C. M. Ripplinger
This study shows chronic nicotine exposure in rabbits increases heart rate, lowers alternans threshold, and reduces sympathetic responses, likely due to hypo-innervation and diminished β-adrenergic responsiveness.
DOI 10.1152/ajpheart.00749.2023