Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart
A. Guevara, C. E. R. Smith, J. L. Caldwell, L. Ngo, L. R. Mott, I.-J. Lee, S. Tapa, Z. Wang, L. Wang, W. R. Woodward, G. A. Ng, B. A. Habecker, C. M. Ripplinger
This study shows chronic nicotine exposure in rabbits increases heart rate, lowers alternans threshold, and reduces sympathetic responses, likely due to hypo-innervation and diminished β-adrenergic responsiveness.
bioRxiv · Nov 23, 2023Physiology