Enterotoxigenic Escherichia coli degrades the host MUC2 mucin barrier to facilitate critical pathogen-enterocyte interactions in human small intestine.
A. Sheikh, T. Wangdi, T. J. Vickers, B. Aaron, M. P. Palmer, M. Miller, S. Kim, C. Herring, R. Simoes, J. A. Crainic, J. Gildersleeve, S. van der Post, G. C. Hansson, J. M. Fleckenstein
This study shows that ETEC's EatA protein degrades the host MUC2 mucin barrier, enabling bacterial access to enterocytes and toxin delivery.
bioRxiv · Oct 22, 2021Microbiology