Author

J. M. Fleckenstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

T. J. Vickers· 4 shared A. Sheikh· 2 shared B. A. Rosa· 1 shared B. Aaron· 1 shared B. Tumala· 1 shared C. Herring· 1 shared C. Storer· 1 shared C. W. Goss· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

T. J. Vickers

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small 1intestinal epithelia

A. Sheikh, B. Tumala, T. J. Vickers, J. C. Martin, B. A. Rosa, S. Sabui, R. D. Simoes, M. Mitreva, C. Storer, E. Tyksen, R. D. Head, W. Beatty, H. M. Said, J. M. Fleckenstein

This study shows that ETEC heat-labile toxin causes long-term intestinal damage beyond diarrhea, affecting nutrient absorption and growth in mice.

bioRxiv · Aug 24, 2022 · PreprintMicrobiology

Enterotoxigenic Escherichia coli degrades the host MUC2 mucin barrier to facilitate critical pathogen-enterocyte interactions in human small intestine.

A. Sheikh, T. Wangdi, T. J. Vickers, B. Aaron, M. P. Palmer, M. Miller, S. Kim, C. Herring, R. Simoes, J. A. Crainic, J. Gildersleeve, S. van der Post, G. C. Hansson, J. M. Fleckenstein

This study shows that ETEC's EatA protein degrades the host MUC2 mucin barrier, enabling bacterial access to enterocytes and toxin delivery.

bioRxiv · Oct 22, 2021Microbiology

Contribution of noncanonical antigens to virulence and adaptive immunity in human infection with enterotoxigenic E. coli

F. M. Kuhlmann, R. O. Laine, S. Afrin, R. Nakajima, M. Akhtar, T. J. Vickers, K. Parker, N. Nizam, V. Grigura, C. W. Goss, P. L. Felgner, D. Rasko, F. Qadri, J. M. Fleckenstein

The paper identifies noncanonical antigens, EtpA and EatA, associated with ETEC virulence and immune response, suggesting their potential inclusion in vaccine design.

bioRxiv · Oct 20, 2020Microbiology

Mechanical Stimuli Affect E. coli Heat Stable Enterotoxin-cyclic GMP Signaling in a Human Enteroid Intestine-Chip Diarrhea Model

l. sunuwar, J. Yin, m. Kasendra, k. karalis, J. Kaper, J. M. Fleckenstein, M. Donowitz

This study shows that fluid flow in an Intestine-Chip model alters intestinal epithelial responses to E. coli heat-stable enterotoxin, increasing cGMP secretion without enhancing intracellular cGMP.

bioRxiv · Sep 18, 2019Microbiology

Molecular determinants of enterotoxigenic Escherichia coli heat-stable toxin secretion and delivery

Y. Zhu, Q. Luo, S. Davis, C. Westra, T. J. Vickers, J. M. Fleckenstein

This study investigates the molecular mechanisms of ST toxin secretion and delivery in ETEC, identifying key factors like TolC and EtpA, and potential therapeutic targets.

bioRxiv · Apr 11, 2018Microbiology