A. Sheikh

Host-derived CEACAM-laden vesicles engage enterotoxigenic E. coli for elimination and toxin neutralization.

The paper shows that host-derived CEACAM-laden vesicles capture ETEC and its toxins, reducing pathogen load and neutralizing toxins during infection.

Repeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic E. coli adhesin

This study identifies key structural and glycosylation features of EtpA, an ETEC adhesin, and shows how antibodies target different epitopes to influence immune responses and pathogen-host interactions.

Therapeutic interventions on human xenografts promote systemic dissemination of oncogenes

The paper shows that therapeutic interventions in human xenografts increase oncogene dissemination, which can be reduced by chromatin deactivating agents.

Microbe-induced plant drought tolerance by ABA-mediated root morphogenesis and epigenetic reprogramming of gene expression

This paper shows that the bacterium Pseudomonas argentinensis sp. SA190 improves Arabidopsis drought tolerance via ABA-mediated root morphogenesis and epigenetic gene priming, with field trials demonstrating enhanced alfalfa performance under desert conditions.

Effects of Oxytocin Receptor Blockade on Dyadic Social Behavior in Monogamous and Non-Monogamous Eulemur

This study investigates the effects of oxytocin receptor blockade on social behavior in monogamous and non-monogamous Eulemur species, finding no support for monogamous pair affiliative behavior differences but suggesting dual blockade effects.

Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small 1intestinal epithelia

This study shows that ETEC heat-labile toxin causes long-term intestinal damage beyond diarrhea, affecting nutrient absorption and growth in mice.

Linker histone H1 regulates defense priming and immunity in plants

This study shows that linker histone H1 variants in Arabidopsis regulate plant immunity by modulating chromatin structure and defense gene expression.

Enterotoxigenic Escherichia coli degrades the host MUC2 mucin barrier to facilitate critical pathogen-enterocyte interactions in human small intestine.

This study shows that ETEC's EatA protein degrades the host MUC2 mucin barrier, enabling bacterial access to enterocytes and toxin delivery.

Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection

This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.

IL-7 is essential for accumulation of antigen-specific CD8 T cells and to generate clonotype-specific effector responses during airway influenza/A infection.

Identification of microRNAs that stabilize p53 in HPV-positive cancer cells

The paper identifies miRNAs that stabilize p53 in HPV-positive cancer cells through high-throughput screening and validates their potential as therapeutics.

Enterobacter sp. SA187 mediates plant thermotolerance by chromatin modification of heat stress genes

This study shows that Enterobacter sp. SA187 enhances Arabidopsis thermotolerance by constitutively priming heat stress genes through chromatin modification, similar to acclimation.