An expanded metabolic pathway for androgen production by host-associated bacteria
T. Wang, S. Ahmad, A. Cruz-Lebron, S. E. Ernst, K. Y. O. Caicedo, Y. Jeong, B. Binion, P. Mbuvi, D. Dutta, F. V. Fernandez-Materan, A. M. Breister, J. W. Lee, J. D. Kang, S. C. Harris, S. Ikegawa, , J. M. Ridlon
This study identifies a bacterial pathway for androgen production, showing that gut and urinary bacteria can convert androstenedione to epitestosterone and testosterone, which promote prostate cancer growth.
bioRxiv · Jun 9, 2024 · PreprintMicrobiology