D. Dutta

Annotating the X-ray diffraction pattern of vertebrate striated muscle

The paper uses an atomic model of the human cardiac thick filament to compute contributions of different components to X-ray diffraction patterns, confirming some interpretations and contradicting others.

An expanded metabolic pathway for androgen production by host-associated bacteria

This study identifies a bacterial pathway for androgen production, showing that gut and urinary bacteria can convert androstenedione to epitestosterone and testosterone, which promote prostate cancer growth.

Kinase activity of histone chaperone APLF maintains steady state of centrosomes in mouse embryonic stem cells

This study identifies APLF as a kinase in mouse embryonic stem cells that regulates centrosome number through PLK4 phosphorylation and FHA domain ATP binding.

Rho and a riboswitch regulate mntP expression evading manganese stress and membrane toxicity

The paper shows Rho terminates transcription at the mntP riboswitch, and manganese activates the riboswitch to restore transcription-translation coupling, preventing membrane toxicity from overexpressed MntP.

Dissection and reconstruction of the colorectal cancer tumor microenvironment

This study reconstructs the colorectal cancer tumor microenvironment using patient-derived organoids and co-cultures, revealing how stromal cells influence cancer behavior and immune evasion.

Bicyclomycin generates ROS and blocks cell division in Escherichia coli

This study shows that bicyclomycin generates reactive oxygen species (ROS) and causes cell filamentation in E. coli by disrupting DNA partitioning and septum formation.

Cryo-EM structure of the human cardiac myosin filament

This paper solves the cryo-EM structure of the human cardiac myosin filament, revealing the arrangement of myosin, cMyBP-C, and titin and their functional interactions.

Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity

This study evaluates how differentiation state and culture conditions affect the neuroregenerative bioactivity of extracellular vesicles (EVs) from neural stem/progenitor cells (NPSCs).

An intrinsic alkalization circuit turns on mntP-riboswitch under manganese stress in Escherichia coli

The paper shows that manganese stress in E. coli activates a circuit involving ammonia production and cytoplasmic alkalization, enhancing mntP-riboswitch activation to improve manganese tolerance.

Sustained Released of Bioactive Mesenchymal Stromal Cell-Derived Extracellular Vesicles from 3D-Printed Gelatin Methacrylate Hydrogels

This study shows that mesenchymal stromal cell-derived extracellular vesicles can be incorporated into 3D-printed hydrogels to enable sustained release and retain bioactivity.

Free spermidine evokes superoxide radicals that manifest toxicity

The paper shows that excess free spermidine generates superoxide radicals, causing toxicity in bacteria lacking the SpeG enzyme, while SpeG enables tolerance by neutralizing spermidine.

Probing the killing potency of tumor-infiltrating lymphocytes on microarrayed autologous tumoroids

This paper develops a microarray-based assay to assess tumor-infiltrating lymphocyte (TIL) activity against autologous tumoroids, identifying responders to immunotherapy.

Mode of action of the antimicrobial peptide Mel4 is independent of Staphylococcus aureus cell membrane permeability

This paper investigates the mechanism of action of the antimicrobial peptide Mel4 and its precursor melimine against Staphylococcus aureus, finding that Mel4 kills bacteria through autolysin release rather than membrane pore formation.

Comparative mode of action of antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa

This study compares the mechanisms of action of melimine and Mel4 against Pseudomonas aeruginosa, showing melimine causes greater membrane disruption and cell lysis.

Chemically Accurate Relative Folding Stability of RNA Hairpins from Molecular Simulations

This study compares simulated and experimental free energies of RNA hairpins to assess force field accuracy and proposes methods to improve simulation convergence.

SIV/SHIV-Zika coinfection does not alter disease pathogenesis in adult non-pregnant Rhesus Macaques

This study investigates HIV-ZIKV coinfection in SIV/SHIV-infected macaques and finds no significant changes in viral loads or cytokine levels, suggesting coinfection does not alter disease pathogenesis.

Escherichia coli β-clamp slows down DNA polymerase I dependent nick translation while accelerating ligation

This study shows that Escherichia coli β-clamp inhibits DNA polymerase I nick translation but promotes ligation during Okazaki fragment maturation.