J. W. Lee

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

The paper identifies QKI as a novel microRNA-binding protein that enhances AGO2/let-7b-mediated gene silencing and suppresses tumor growth.

This study engineers Saccharomyces cerevisiae to simultaneously ferment xylo-oligosaccharides, xylose, and acetate, producing 60% more ethanol and 12% less xylitol than the control strain.

This study shows miR-155 shifts PGE2/PGD2 balance towards an oncogenic state by regulating enzymes involved in prostaglandin synthesis.

This study identifies TM4SF5's role in modulating SIRT1 and STAT3 signaling during NAFL to NASH progression, showing age-dependent effects and potential therapeutic targets.

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

The paper examines mitochondrial morphology-related gene expression during murine ESC differentiation and proposes an index based on Mfn2/Dnm1L ratio to reflect mitochondrial changes.

The paper identifies transcriptomes of major renal collecting-duct cell types in mice using single-cell RNA-Seq and creates an online gene-expression database.