GABA, glucose and insulin orchestrate CD4+ T cells effector functions
Z. Jin, H. Hammoud, A. K. Bhandage, S. V. Korol, O. Trujeque-Ramos, S. Koreli, A. I. Chowdhury, F. A. Sandbaumhuter, E. Jansson, P. Bergstein, P. Andren, M. Kamali-Moghaddam, B. Birnir
This study shows that GABA, glucose, and insulin together regulate CD4+ T cell metabolic activity and inflammatory molecule release, with SGLTs playing a key role in glucose-dependent effects.
bioRxiv · Apr 18, 2023 · PreprintPhysiology