Z. Jin

Harmonic imaging for nonlinear detection of acoustic biomolecules

This study introduces harmonic xAM (HxAM) imaging to improve GV detection sensitivity and imaging depth in vivo.

Ultrasound-actuated drug delivery with acoustic percolation switches

This paper introduces a drug delivery system using ultrasound to trigger release from hydrogels containing gas vesicles, demonstrating targeted delivery in a rat colitis model.

Directed Evolution of Acoustic Reporter Genes Using High-Throughput Acoustic Screening

The paper evolves acoustic reporter genes using high-throughput acoustic screening to enhance nonlinear ultrasound scattering.

Ultrasonic reporters of calcium for deep tissue imaging of cellular signals

This paper introduces a genetically encoded ultrasonic calcium reporter (URoC) for noninvasive in vivo imaging of calcium signaling in mammals.

Dense Sampling of Taxa and Genomes Untangles the Phylogenetic Backbone of a Non-model Plant Lineage Rife with Deep Hybridization and Allopolyploidy

The paper constructs a robust phylogenetic backbone for the Campanuleae tribe using genomic data and phylogenetic methods, revealing hybridization and allopolyploidy as key drivers of diversification.

Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder Afrotheria

This study analyzes sirenian genomes to identify genomic adaptations to aquatic life and conservation challenges.

GABA, glucose and insulin orchestrate CD4+ T cells effector functions

This study shows that GABA, glucose, and insulin together regulate CD4+ T cell metabolic activity and inflammatory molecule release, with SGLTs playing a key role in glucose-dependent effects.

Long-term reliable neural decoding based on flexible implantable microelectronics and machine learning for seizure prediction application

This study combines flexible implantable microelectronics with machine learning to achieve reliable long-term neural decoding for seizure prediction in epileptic mice.

Aberration modeling in deep learning for volumetric reconstruction of light-field microscopy

This paper introduces AM-VCD, a deep learning network that corrects spherical aberration in light-field microscopy to enable high-speed 3D imaging with uniform resolution.

Magnetic Resonance Fingerprinting based Thermometry (MRFT): application to ex vivo imaging near DBS leads

This paper introduces MRFT, a T1-based magnetic resonance thermometry method, and demonstrates its accuracy in estimating temperature near DBS leads compared to gold standard probes.

Heavy metal pollution characteristics of soil around a copper-nickel mine tailings pond in the northwest arid area of China and evaluation of desert phytoremediation potential

This study evaluates heavy metal pollution in soil near a copper-nickel mine tailings pond and assesses the phytoremediation potential of desert plants.

A di-arginine additive for dissociation of gold nanoparticle aggregates: A matrix-insensitive approach with applications in protease detection

This paper introduces a di-arginine additive for dissociating gold nanoparticle aggregates in complex matrices, enabling sensitive protease detection in biological fluids.

Microbiota-stimulated Interleukin-22 regulates brain neurons and protects against stress-induced anxiety

This study identifies IL-22 as a key immune-to-brain signal that reduces stress-induced anxiety by acting on septal neurons.

Geometric effects in gas vesicle buckling under ultrasound

This study investigates how the geometry of gas vesicles affects their buckling behavior under ultrasound, showing diameter has an inverse cubic effect on buckling pressure while length has minimal impact.

An attempt to find the correlations between body weight and the composition of gut microbiota in Zhejiang and Shanghai

This study analyzes gut microbiota composition in individuals from Zhejiang and Shanghai to explore its potential link to obesity and BMI, finding some correlations but no significant differences.

A miniaturized ultrasound transducer for monitoring full-mouth oral health: a preliminary study

This study develops a miniaturized ultrasound transducer for full-mouth oral health monitoring, demonstrating high-resolution imaging and accurate gingival thickness measurement.

Ultrafast amplitude modulation for molecular and hemodynamic ultrasound imaging

This paper introduces an ultrafast nonlinear ultrasound imaging technique that improves sensitivity, field of view, and frame rate for molecular and hemodynamic imaging.

Genomically mined acoustic reporter genes enable real-time in vivo monitoring of tumors and tumor-homing probiotics

The paper develops improved acoustic reporter genes for real-time in vivo tumor and therapeutic bacteria monitoring in mouse models.

Novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives

This study identifies a novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives through crystallography and mass spectrometry, revealing a unique covalent adduct formation and by-product generation.

Chemical Systems Biology Reveals Mechanisms of Glucocorticoid Receptor Signaling

The paper uses Ligand Class Analysis to identify target genes and coregulator interactions of glucocorticoid receptor ligands, revealing mechanisms linking ligand structure to physiological outcomes.

Adipose tissue macrophages orchestrate β cell adaptation in obesity through secreting miRNA-containing extracellular vesicles

This study shows that adipose tissue macrophage-derived extracellular vesicles containing miRNA-155 regulate β cell function and proliferation in obesity.

Relationship between Anti-Spike Protein Antibody Titers and SARS-CoV-2 In Vitro Virus Neutralization in Convalescent Plasma

This study finds a strong correlation between anti-RBD and anti-ECD IgG titers and in vitro virus neutralization titers in convalescent plasma, suggesting these titers can serve as surrogates for neutralizing activity.

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug Carmofur

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

Visual function restoration in genetically blind mice via endogenous cellular reprogramming

This study restores vision in blind mice by reprogramming Muller glia to retinal neurons, demonstrating a potential treatment for end-stage retinal degeneration.

Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

Structure of Mpro from COVID-19 virus and discovery of its inhibitors

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

Acoustogenetic Control of CAR T Cells via Focused Ultrasound

This paper develops an acoustogenetic method using focused ultrasound to control CAR T cells, enabling noninvasive activation to treat cancer with reduced off-tumor effects.

The characterization of a humanized rabbit anti-TNF α monoclonal antibody?A nationwide RA treatment drug study

This study develops a rabbit-derived anti-TNFα monoclonal antibody (HZ3M) showing improved neutralizing activity and longer half-life compared to existing therapies like Humira.

Depression, GABA and age correlate with the plasma levels of inflammatory markers.

The paper examines correlations between depression, age, GABA levels, and plasma inflammatory markers, identifying potential peripheral biomarkers for depression.

GABAA receptor-mediated currents and hormone mRNAs in cells expressing more than one hormone transcript in intact human pancreatic islets

The paper examines GABAA receptor-mediated currents and hormone mRNA expression in human pancreatic islet cells expressing multiple hormone transcripts, finding that iGABAAR properties are specific to {beta} cells.