Mitochondrial Calcium Uptake Declines during Aging and is Directly Activated by Oleuropein to Boost Energy Metabolism and Skeletal Muscle Performance
G. Gherardi, A. Weiser, F. Bermont, E. Migliavacca, B. Brinon, G. E. Jacot, A. Hermant, M. Sturlese, L. Nogara, D. Barron, B. Blaauw, S. Moro, R. Rizzuto, J. N. Feige, C. Mammucari, U. DeMarchi
This study identifies Oleuropein as a MCU activator that enhances mitochondrial function and muscle performance in both young and aged organisms.
bioRxiv · Feb 24, 2023Physiology