Author

B. Breton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Le Gouill· 2 shared M. Bouvier· 2 shared A. Inoue· 1 shared A. Mancini· 1 shared A. Rizk· 1 shared A. S. Hauser· 1 shared B. Plouffe· 1 shared C. Avet· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. Le Gouill

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2 papers

Recent·Most cited

Vasopressin V2 is a promiscuous G protein-coupled receptor that is biased by its peptide ligands

F. M. Heydenreich, B. Plouffe, A. Rizk, D. Milic, J. Zhou, B. Breton, C. Le Gouill, A. Inoue, M. Bouvier, D. Veprintsev

The paper shows that the vasopressin V2 receptor activates multiple G proteins and that its signaling can be biased by ligand structure.

bioRxiv · Jan 28, 2021 · PreprintPharmacology & Toxicology

Effector membrane translocation biosensors reveal G protein and β-arrestin coupling profiles of 100 therapeutically relevant GPCRs

C. Avet, A. Mancini, B. Breton, C. Le Gouill, A. S. Hauser, C. Normand, H. Kobayashi, F. Gross, M. Hogue, V. Lukasheva, S. St-Onge, M. Carrier, M. Heroux, S. Morissette, E. Fauman, , M. Bouvier

The paper develops EMTA biosensors to profile G protein and β-arrestin coupling of 100 GPCRs, revealing diverse signaling profiles and drug-target interactions.

bioRxiv · Apr 20, 2020Pharmacology & Toxicology