Author

B. C. Mounce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Assay:proteomics· 1

Frequent Co-Authors

M. R. Firpo· 2 shared N. J. LoMascolo· 2 shared O. S. Omoba· 2 shared V. Mastrodomenico· 2 shared A. Jaochimiak· 1 shared A. V. Ivanov· 1 shared B. C. Dickinson· 1 shared B. L. Fung· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

M. R. Firpo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Polyamines and eIF5A hypusination facilitate SREBP2 translation and cholesterol synthesis to enhance enterovirus attachment and infection

M. R. Firpo, M. J. Petite, N. J. LoMascolo, P. Shah, B. C. Mounce

This study shows polyamines enhance CVB3 infection by promoting SREBP2 translation and cholesterol synthesis, linking polyamine and cholesterol homeostasis.

bioRxiv · Nov 1, 2021 · PreprintMicrobiology

Polyamines mediate enterovirus attachment directly and indirectly through cellular heparan sulfate synthesis.

B. M. Hulsebosch, O. S. Omoba, N. J. LoMascolo, B. C. Mounce

This study shows polyamines enhance enterovirus attachment directly and by promoting heparan sulfate synthesis on cell surfaces.

bioRxiv · Oct 31, 2021 · PreprintMicrobiology

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

N. Drayman, K. A. Jones, S.-A. Azizi, H. M. Froggatt, K. Tan, N. Ivanova Maltseva, S. Chen, V. Nicolaescu, S. Dvorkin, K. Furlong, R. S. Kathayat, M. R. Firpo, V. Mastrodomenico, E. A. Bruce, M. M. Schmidt, , S. Tay

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

bioRxiv · Aug 31, 2020Microbiology

Novel ionophores active against La Crosse virus identified through rapid antiviral screening

Z. J. Sandler, M. N. Vu, V. D. Menachery, B. C. Mounce

This paper identifies novel antivirals, including valinomycin, active against La Crosse virus and other viruses by disrupting potassium ion homeostasis.

Antimicrobial Agents and Chemotherapy · May 21, 2020Peer-reviewedMicrobiology

Virion-associated spermidine transmits with Rift Valley fever virus particles to maintain infectivity

V. Mastrodomenico, J. J. Esin, S. Qazi, O. S. Omoba, B. L. Fung, M. A. Khomutov, A. V. Ivanov, S. Mukhopadhyay, B. C. Mounce

This study identifies spermidine as a critical polyamine associated with Rift Valley fever virus particles that maintains infectivity, highlighting a new antiviral target.

bioRxiv · Jan 23, 2020 · PreprintMicrobiology