K. Tan

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

This study maps human bone marrow niches using single-cell transcriptomics and proteomic imaging, identifying distinct cellular environments and their roles in hematopoiesis and AML.

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma

This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.

Oncogenic RAS-Pathway Activation Drives Oncofetal Reprogramming and Creates Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

This study identifies oncofetal reprogramming in juvenile myelomonocytic leukemia, linking RAS-pathway activation to fetal gene expression and revealing CD52 as a therapeutic target.

Acetyl-CoA carboxylase 1-dependent lipogenesis drives breast cancer progression

This study shows ACC1 drives breast cancer progression through lipogenesis, with ACC1 knockout reducing tumor growth and altering lipid profiles in both mouse models and human cells.

Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility

The paper shows that HIV-1 MPER-targeting antibodies generated by vaccines lack structural constraints needed to access the MPER, despite having bnAb-like paratopes.

Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signaling

This study examines how mutations in the RAR ligand binding domain affect retinoic acid signaling and tumorigenesis in breast fibroepithelial tumors.

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

HSP90.6 is involved in grain filling via carbon and nitrogen metabolism in maize.

HSP90.6 regulates maize grain filling by affecting 26S proteasome-mediated nitrogen recycling and GF14-6-mediated carbon metabolism.

Endothelial-immune crosstalk contributes to vasculopathy in non-alcoholic fatty liver disease

This study investigates endothelial-immune interactions in NAFLD, showing increased chemokine expression and immune cell infiltration, and demonstrates that targeting the CXCL12-CXCR4 axis can restore endothelial barrier function.

Temporal transcriptional response of Candida glabrata during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and drug resistance

The paper maps transcriptional responses of Candida glabrata during macrophage infection and identifies CgXbp1 as a key regulator of virulence and drug resistance.

Decade-long remissions of leukemia sustained by the persistence of activated CD4+ CAR T-cells

This study tracks long-term persistence of CD4+ CAR T-cells in CLL patients, showing their role in sustained remission and clonal stability over 10 years.

Epigenetic state determines inflammatory sensing in neuroblastoma

The paper shows that epigenetic states in neuroblastoma cells determine their response to inflammatory stimuli, with mesenchymal states being more responsive than adrenergic states.

4D chromosome reconstruction elucidates the spatial reorganization of the mammalian X-chromosome

The paper uses 4DHiC to reconstruct 3D chromosome dynamics, showing X-chromosome reorganization during inactivation involves persistent smaller structures and Xist RNA diffusion.

Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia

The paper identifies synergistic genetic targets in Ph-like B-ALL using network analysis to guide combination therapy, showing improved efficacy in preclinical models.

Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of KMT2A-rearranged leukemia

This study uses single-cell multi-omics to identify lineage plasticity and stem-cell-like blasts in KMT2A-rearranged leukemia, linking these features to poor prognosis in infants.

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers

This study identifies and characterizes noncoding mutations in pediatric cancers using a computational framework and experimental validation, revealing their role in deregulating cis-regulatory landscapes.

A popular Indian clove-based mosquito repellent is a false economy

The paper tests a homemade clove-based mosquito repellent and finds it ineffective, while a higher concentration of eugenol shows moderate repellency, but DEET remains more effective and cheaper.

Ingredients in Victoria’s Secret Bombshell and Ivanka Trump eaux de parfums that repel mosquitoes

The paper identifies two fragrance ingredients in Victoria’s Secret Bombshell and Ivanka Trump eaux de parfums that repel mosquitoes, but warns against using them as off-label repellents.