Author

N. Drayman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

S. Tay· 5 shared G. Randall· 3 shared V. Nicolaescu· 3 shared A. Mohamed· 2 shared B. C. Dickinson· 2 shared C. Dann· 2 shared D. Silva· 2 shared D. Yang· 2 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

S. Tay

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6 papers

Recent·Most cited

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

L. C. Nguyen, D. M. Renner, D. Silva, D. Yang, N. Parenti, K. M. Medina, V. Nicolaescu, H. Gula, N. Drayman, A. Valdespino, A. Mohamed, C. Dann, K. Wannemo, L. Robinson-Mailman, A. Gonzalez, , S. R. Weiss

This study compares how SARS-CoV-2 and other betacoronaviruses activate the IRE1α/XBP1 ER stress pathway in human lung cells, finding that SARS-CoV-2 only partially activates it, potentially evading host immune detection.

bioRxiv · Dec 30, 2021 · PreprintMicrobiology

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression

S. Walter, V. Franke, N. Drayman, E. Wyler, S. Tay, M. Landthaler, A. Akalin, A. Ensser, F. Full

This study shows herpesviruses induce DUX4 expression, which drives viral gene expression by mimicking embryonic genome activation.

bioRxiv · Mar 24, 2021 · PreprintMicrobiology

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response

L. C. Nguyen, D. Yang, V. Nicolaescu, T. Best, S. Chen, J. B. Friesen, N. Drayman, A. Mohamed, C. Dann, D. Silva, H. Gula, K. A. Jones, J. M. Millis, B. C. Dickinson, S. Tay, , M. R. Rosner

This study shows that cannabidiol inhibits SARS-CoV-2 replication and enhances the host innate immune response in lung cells and human patients.

bioRxiv · Mar 10, 2021 · PreprintMicrobiology

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

N. Drayman, K. A. Jones, S.-A. Azizi, H. M. Froggatt, K. Tan, N. Ivanova Maltseva, S. Chen, V. Nicolaescu, S. Dvorkin, K. Furlong, R. S. Kathayat, M. R. Firpo, V. Mastrodomenico, E. A. Bruce, M. M. Schmidt, , S. Tay

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

bioRxiv · Aug 31, 2020Microbiology

HSV-1 single cell analysis reveals anti-viral and developmental programs activation in distinct sub-populations

N. Drayman, P. Patel, L. Vistain, S. Tay

The paper uses single-cell analysis to show HSV-1 infection leads to distinct transcriptional programs in different cell sub-populations, including anti-viral responses and reprogramming to an embryonic-like state.

bioRxiv · Mar 5, 2019Microbiology

Recombination between co-infecting herpesviruses occurs where replication compartments coalesce

E. Tomer, E. M. Cohen, N. Drayman, A. Afriaat, M. D. Weitzman, A. Zaritsky, O. Kobiler

This study shows that herpesvirus recombination occurs when replication compartments coalesce, revealing spatial and temporal requirements for inter-genomic recombination.

bioRxiv · Dec 25, 2018 · PreprintMicrobiology