S. Tay

Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport

This study shows CLDN2 upregulation during pancreatitis limits disease progression by enhancing tight junction-controlled fluid transport in pancreatic ductal epithelium.

OrganoID: a versatile deep learning platform for tracking and analysis of single-organoid dynamics

OrganoID automatically tracks and analyzes single-organoid dynamics in microscopy images, showing high accuracy in counting, sizing, and morphology analysis across multiple organoid types.

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

This study compares how SARS-CoV-2 and other betacoronaviruses activate the IRE1α/XBP1 ER stress pathway in human lung cells, finding that SARS-CoV-2 only partially activates it, potentially evading host immune detection.

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression

This study shows herpesviruses induce DUX4 expression, which drives viral gene expression by mimicking embryonic genome activation.

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response

This study shows that cannabidiol inhibits SARS-CoV-2 replication and enhances the host innate immune response in lung cells and human patients.

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

Quantification of proteins, protein complexes and mRNA in single cells by proximity-sequencing

This paper introduces Prox-seq, a method to measure proteins, protein complexes, and mRNA in single cells, demonstrating its ability to detect 91 protein complexes and thousands of mRNAs in T-cells and B-cells.

High-throughput isolation and sorting of gut microbes reduce biases of traditional cultivation strategies

This study develops a microfluidic platform to isolate and sort gut microbes, increasing richness and rare taxa representation compared to traditional methods.

HSV-1 single cell analysis reveals anti-viral and developmental programs activation in distinct sub-populations

The paper uses single-cell analysis to show HSV-1 infection leads to distinct transcriptional programs in different cell sub-populations, including anti-viral responses and reprogramming to an embryonic-like state.