Author

B. De Strooper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Liston· 2 shared E. Pasciuto· 2 shared J. Dooley· 2 shared L. Kouser· 2 shared L. Mascali· 2 shared L. Yshii· 2 shared M. Holt· 2 shared M. Marino· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. Liston

Mutual co-authors in cluster

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3 papers

Recent·Most cited

The AppNL-G-F mouse model of Alzheimer's disease is refractory to regulatory T cell treatment

L. Yshii, L. Mascali, L. Kouser, P. Lemaitre, M. Marino, J. Dooley, O. Burton, J. Haughton, Z. Callaerts-Vegh, B. de Strooper, M. Holt, E. Pasciuto, A. Liston

This study shows that regulatory T cell therapy does not improve Alzheimer's disease progression in AppNL-G-F mice, suggesting limited therapeutic potential for this model.

bioRxiv · Mar 11, 2022 · PreprintImmunology

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

L. Yshii, E. Pasciuto, P. Bielefeld, L. Mascali, P. Lemaitre, M. Marino, J. Dooley, L. Kouser, S. Verschoren, V. Lagou, H. Kemps, P. Gervois, A. de Boer, O. Burton, J. Wahis, , A. Liston

This study delivers IL2 to astrocytes in the brain to increase resident Tregs and protect against neuroinflammation without affecting the peripheral immune system.

bioRxiv · Feb 28, 2022Immunology

The Amyloid Precursor Protein is a conserved Wnt receptor

T. Liu, M. Nicolas, T. Zhang, H. Rice, A. Soldano, A. Claeys, I. Petrova, L. Fradkin, B. De Strooper, B. A. Hassan

This study identifies Wnt ligands as binding partners of APP, showing that Wnt3a stabilizes APP while Wnt5a targets it for degradation, with functional consequences for neuronal development.

bioRxiv · Jan 18, 2021Cell Biology