Author

E. Pasciuto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Assay:flow cytometry· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Liston· 3 shared J. Dooley· 3 shared O. Burton· 3 shared P. Lemaitre· 3 shared B. de Strooper· 2 shared C. Whyte· 2 shared L. Kouser· 2 shared L. Mascali· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

A. Liston

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3 papers

Recent·Most cited

The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program

O. Burton, O. Bricard, S. Tareen, V. Gergelits, S. Andrews, C. P. Roca, C. Whyte, S. Junius, A. Brajic, E. Pasciuto, M. Ali, P. Lemaitre, S. M. Schlenner, H. Ishigame, B. Brown, , A. Liston

The paper analyzes tissue-resident regulatory T cells (Tregs) in non-lymphoid organs, showing they share phenotypes, transient residency, and TCR sequences, with tissue-agnostic re-entry capabilities.

bioRxiv · Aug 14, 2023Immunology

The AppNL-G-F mouse model of Alzheimer's disease is refractory to regulatory T cell treatment

L. Yshii, L. Mascali, L. Kouser, P. Lemaitre, M. Marino, J. Dooley, O. Burton, J. Haughton, Z. Callaerts-Vegh, B. de Strooper, M. Holt, E. Pasciuto, A. Liston

This study shows that regulatory T cell therapy does not improve Alzheimer's disease progression in AppNL-G-F mice, suggesting limited therapeutic potential for this model.

bioRxiv · Mar 11, 2022 · PreprintImmunology

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

L. Yshii, E. Pasciuto, P. Bielefeld, L. Mascali, P. Lemaitre, M. Marino, J. Dooley, L. Kouser, S. Verschoren, V. Lagou, H. Kemps, P. Gervois, A. de Boer, O. Burton, J. Wahis, , A. Liston

This study delivers IL2 to astrocytes in the brain to increase resident Tregs and protect against neuroinflammation without affecting the peripheral immune system.

bioRxiv · Feb 28, 2022Immunology