A. Liston

Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas

This study identifies a rare pancreatic tissue-resident regulatory T cell population that exhibits both anti-tumour and pro-repair functions in the exocrine pancreas.

The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program

The paper analyzes tissue-resident regulatory T cells (Tregs) in non-lymphoid organs, showing they share phenotypes, transient residency, and TCR sequences, with tissue-agnostic re-entry capabilities.

Investigating the effects of radiation, T cell depletion, and bone marrow transplantation on murine gut microbiota

This study examines how radiation, T cell depletion, and bone marrow transplantation affect the gut microbiota in mice, revealing region-specific changes and the impact of T cells on microbial composition.

The AppNL-G-F mouse model of Alzheimer's disease is refractory to regulatory T cell treatment

This study shows that regulatory T cell therapy does not improve Alzheimer's disease progression in AppNL-G-F mice, suggesting limited therapeutic potential for this model.

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

This study delivers IL2 to astrocytes in the brain to increase resident Tregs and protect against neuroinflammation without affecting the peripheral immune system.

Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loop

This paper shows that antiangiogenic immunotherapies convert postcapillary venules into high-endothelial venules that support TCF1+ T cell niches through a feed-forward loop involving CD8 and NK cells.

Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy

This study identifies distinct CD8+T cell states in cancer patients using multi-omics data, showing that dysfunctional states resist immunotherapy while exhausted states can be targeted with specific treatments.

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

This study identifies context-dependent effects of IL-2 on immune circuits by rewiring its production sources in mice, revealing distinct cellular responses and potential adverse effects.

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

This study shows that a booster dose of the ChAdOx1 nCoV-19 vaccine increases immune response in aged mice compared to a single dose.

Analysis of paralogs in target enrichment data pinpoints multiple ancient polyploidy events in Alchemilla s.l. (Rosaceae)

The paper develops an automated orthology inference method to detect ancient polyploidy events in Alchemilla s.l. by analyzing paralogs in target enrichment data.

Intrinsic defects in lymph node stromal cells underpin poor germinal center responses during aging

This study shows that aging impairs lymph node stromal cells' ability to respond to vaccination, limiting germinal center formation and antibody production.

Completing Linneaus's inventory of the Swedish insect fauna: only 5,000 species left?

The paper estimates the Swedish insect fauna contains around 33,000 species, with 5,000 remaining to be discovered, highlighting taxonomic and ecological biases in current knowledge.

Target Capture Sequencing Unravels Rubus Evolution

This study uses target capture sequencing to estimate the phylogeny of Rubus species, revealing subgeneric paraphyly and historical biogeographic patterns.

Revisiting the Origin of the Octoploid Strawberry

The paper reanalyzes the origin of octoploid strawberries, finding two diploid progenitors instead of four, and identifies flaws in a previous phylogenetic approach.

Machine learning identifies the immunological signature of Juvenile Idiopathic Arthritis

This study uses machine learning to identify an immunological signature specific to Juvenile Idiopathic Arthritis (JIA) with ~90% diagnostic accuracy.

Mice deficient in nucleoporin Nup210 develop peripheral T cell alterations

This study identifies Nup210 as essential for peripheral T cell homeostasis in mice, with no major phenotypes observed despite its evolutionary conservation.

Both functional trait divergence and trait plasticity confer polyploid advantage in changing environments

The paper tests how functional trait divergence and plasticity contribute to polyploid fitness advantage in changing environments using wild strawberry species.

Repeated translocation of a gene cassette drives sex chromosome turnover in strawberries

The paper identifies a female-specific gene cassette that repeatedly translocates across chromosomes in strawberries, driving sex chromosome turnover through a 'move-lock-grow' mechanism.