Furin controls β cell function via mTORC1 signaling
B. Brouwers, I. Coppola, K. Vints, B. Dislich, N. Jouvet, L. Van Lommel, N. V. Gounko, L. Thorrez, F. Schuit, S. F. Lichtenthaler, J. L. Estall, J. Declercq, B. Ramos-Molina, J. W. M. Creemers
This study shows that furin is essential for β cell function through mTORC1 signaling, as its absence leads to glucose intolerance and β cell dysfunction.
bioRxiv · Apr 9, 2020Physiology