Author

J. L. Estall

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:metabolism & bioenergetics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

N. Jouvet· 2 shared A. Gunes· 1 shared A. Helness· 1 shared A. Pacis· 1 shared A. Pause· 1 shared B. Brouwers· 1 shared B. Dislich· 1 shared B. Nguyen· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersPhysiology

N. Jouvet

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A conserved role of hnRNPL in regulating alternative splicing of transcriptional regulators necessary for B cell activation

P. G. Subramani, J. Fraszczak, A. Helness, J. L. Estall, T. Moroy, J. M. Di Noia

This study shows hnRNPL regulates alternative splicing of transcriptional regulators in B cells, essential for activation and antibody responses.

bioRxiv · Sep 24, 2023Immunology

Expression of a tetracycline-controlled transactivator (Tet-On/Off system) in beta cells reduces insulin expression and secretion in mice

N. Jouvet, K. Bouyakdan, C. Baldwin, J. Marcinkiewicz, T. Alquier, J. L. Estall

This study shows that expressing tetracycline-controlled transactivators in beta cells reduces insulin expression and secretion in mice, highlighting concerns about their use in genome editing.

bioRxiv · Feb 10, 2021Physiology

FLCN Gene Ablation Reduces Fibrosis and Inflammation in a Diet-Induced NASH Model

M. Paquette, M. Yan, L. El-Houjeiri, M. Biondini, J. M. J. Ramirez-Reyes, A. Pacis, H. Jeong, J. L. Estall, P. M. Siegel, A. Pause

This study shows that FLCN gene ablation reduces fibrosis and inflammation in a diet-induced NASH model by enhancing autophagy and lysosomal biogenesis.

bioRxiv · Sep 10, 2020 · PreprintPathology

Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver disease

H. Zhang, M. Leveille, E. Courty, A. Gunes, B. Nguyen, J. L. Estall

This study compares two dietary models of murine NAFLD/NASH, showing differences in metabolic syndrome and liver disease severity, but similar tumour burdens in liver cancer models.

bioRxiv · Jun 5, 2020Physiology

Furin controls β cell function via mTORC1 signaling

B. Brouwers, I. Coppola, K. Vints, B. Dislich, N. Jouvet, L. Van Lommel, N. V. Gounko, L. Thorrez, F. Schuit, S. F. Lichtenthaler, J. L. Estall, J. Declercq, B. Ramos-Molina, J. W. M. Creemers

This study shows that furin is essential for β cell function through mTORC1 signaling, as its absence leads to glucose intolerance and β cell dysfunction.

bioRxiv · Apr 9, 2020Physiology