PhysiologybioRxiv
Expression of a tetracycline-controlled transactivator (Tet-On/Off system) in beta cells reduces insulin expression and secretion in mice
N. Jouvet, K. Bouyakdan, C. Baldwin…·J. L. Estall
This study shows that expressing tetracycline-controlled transactivators in beta cells reduces insulin expression and secretion in mice, highlighting concerns about their use in genome editing.
DOI 10.2337/db21-0147