Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility
J. Talwar, D. Laub, M. Pagadala, A. Castro, M. Lewis, G. E. Luebeck, B. Gorman, C. Pan, F. N. Dong, K. Markianos, R. Hauger, S. Pyarajan, P. S. Tsao, G. P. Morris, R. M. Salem, , H. Carter
This study shows that MHC-I autoimmune alleles are associated with reduced melanoma risk and later diagnosis age, independent of existing polygenic risk scores.
bioRxiv · Aug 12, 2021Cancer Biology