M. Lewis

Barriers to cascade screening in people at risk of Thoracic Aortic Disease: a mixed methods evaluation from the DECIDE-TAD initiative

This study identifies barriers to cascade screening for thoracic aortic disease using mixed methods, finding low uptake due to awareness, health literacy, and cost concerns.

Coupling mountain pine beetle and forest population dynamics predicts transient outbreaks that are likely to increase in number with climate change

This study couples mountain pine beetle and forest dynamics to predict climate-driven transient outbreaks and their increasing frequency with reduced forest resilience.

Identifying signals of memory from observations of animal movements

The paper reviews methods to incorporate memory into movement models using wildlife tracking data and provides code examples for implementation.

Neuro-Regenerative Behavior of Adipose-Derived Stem Cells in Aligned Collagen I Hydrogels

This study evaluates the neuro-regenerative potential of adipose-derived stem cells in aligned collagen I hydrogels for peripheral nerve repair.

Colorectal cancer detection and treatment with engineered probiotics

This paper demonstrates the use of engineered probiotics to detect and treat colorectal cancer by monitoring their colonization and delivering therapeutic molecules.

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.

From Policy to Practice: Tracking an Open Science Funding Initiative

This paper evaluates the effectiveness of the ASAP initiative in improving research output sharing through open science compliance monitoring.

GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program

This study identifies distinct interactions of GEMC1 and MCIDAS with SWI/SNF subcomplexes in multiciliated cell differentiation and shows that these interactions are required for MCC-specific transcriptional regulation.

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta

This study compares disease severity and viral load in rhesus macaques infected with SARS-CoV-2 Delta, Omicron BA.1, and BA.2 variants, finding Omicron variants cause less severe disease with lower viral loads.

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques

The combination of molnupiravir and nirmatrelvir inhibits SARS-CoV-2 replication and shedding more effectively than individual treatments in the rhesus macaque model.

Rational optimization of a transcription factor activation domain inhibitor

This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.

The global exposure of species ranges and protected areas to forest management

This study shows that forest management practices affect species ranges and protected areas, potentially increasing extinction risks.

Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant viral replication in rhesus macaques

An intranasal SARS-CoV-2 beta variant subunit booster vaccine induced protective immunity against beta variant infection in rhesus macaques one year after initial vaccination.

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

The paper uses genetically diverse mice to model varied innate immune responses to SARS-CoV-2 infection, showing differences in survival, viral replication, and cytokine profiles.

Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery Against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques

This study evaluates the protective efficacy of oral SARS-CoV-2 delivery in rhesus macaques against respiratory challenges, finding limited immunogenicity and partial protection.

Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility

This study shows that MHC-I autoimmune alleles are associated with reduced melanoma risk and later diagnosis age, independent of existing polygenic risk scores.

Mitophagy antagonism by Zika virus reveals Ajuba as a regulator of PINK1-Parkin signaling, PKR-dependent inflammation, and viral invasion of tissues.

This study shows ZIKV NS5 inhibits mitophagy by blocking Ajuba's role in PINK1-Parkin signaling, leading to increased inflammation and viral spread.

Areas of global importance for terrestrial biodiversity, carbon, and water

The paper identifies global terrestrial areas prioritized for conservation to maximize synergies between biodiversity, carbon retention, and water provisioning.

SULF1 suppresses Wnt3A-driven growth of bone metastatic prostate cancer in perlecan-modified 3D cancer-stroma-macrophage triculture models

Identification of H3N2 NA and PB1-F2 genetic variants and their association with disease symptoms in the 2014-15 influenza season

The paper identifies H3N2 NA and PB1-F2 genetic variants and links their presence to increased cough and shortness of breath in patients during the 2014-15 influenza season.

Differential Disease Severity and Whole Genome Sequence Analysis for Human Influenza A/H1N1pdm Virus in 2015-2016 Influenza Season

The paper analyzes whole genome sequences of H1N1pdm viruses from 2015-2016 to compare disease severity between Baltimore and Taiwan, finding 6B.2 viruses associated with more severe symptoms in Taiwan.

Evaluating the ecological impacts of pesticide seed treatments on arthropod communities in a grain crop rotation

This study evaluates the ecological impacts of pesticide seed treatments on arthropod communities in a grain crop rotation, finding variable effects on community structure and suggesting potential for recovery delays.

The Energetics of Molecular Adaptation in Transcriptional Regulation

The paper links mutations in a transcriptional repressor to biophysical parameters, showing how changes in free energy predict gene expression and epistasis.

Tuning transcriptional regulation through signaling: A predictive theory of allosteric induction

The paper develops a predictive theory of allosteric transcriptional regulation using the Monod-Wyman-Changeux model and validates it with experimental data on bacterial simple repression motifs.