C. Pan

The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells

This study shows PGE2 inhibits glucose-stimulated insulin secretion in β-cells via the EP2/4-Kv2.2 pathway by modulating Kv2.2 channels through PKA.

Effects of different feeding methods on serum biochemical indexes, metabolic indexes, immune indexes, and intestinal microorganisms of Nanjiang yellow goats

This study examines how different feeding methods affect serum biochemical, immune, and metabolic indicators and intestinal microbiota in Nanjiang Yellow goats, finding significant differences in metabolites, immune factors, and microbial composition.

Differential substrate affinity and catabolite repression enable preferential use of urea by ammonia-oxidizing bacteria

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.

Single-cell precision nanotechnology in vivo

This study demonstrates DNA origami can be directed in vivo to target immune cells and cancer metastases, showing potential for precision drug delivery.

Extracting herbicide and antibiotic natural products from a plant-microbe interaction system

This study identifies a plant-microbe interaction system where a rhizosphere bacterium produces molecules with dual antibiotic and herbicide functions, offering insights into novel natural product discovery.

Persistent biofluid small molecule alterations induced by Trypanosoma cruzi infection are not restored by antiparasitic treatment

This study identifies persistent urine metabolome alterations in T. cruzi-infected mice that are not reversed by antiparasitic treatment, suggesting urine as a potential diagnostic tool for Chagas Disease.

High-resolution structure of mouse radial spoke and its in-situ structure in ependymal cilia revealed by cryo-EM and cryo-ET

The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.

Electron transport inhibition increases cellular dependence on purine transport and salvage

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

Prevalence of Slam-dependent hemophores in Gram-negative bacteria

The paper identifies HphAs as a new class of hemophores in Gram-negative bacteria, showing their structural similarity to hemophilin1 and dependence on Slam for secretion.

Stromal resistance to castration-induced prostate regression in a mouse model of benign prostatic hyperplasia

This study shows that stromal compartments in a mouse model of BPH are resistant to castration-induced regression, suggesting the need for additional therapies.

Membrane-Bound O-Acyltransferase 7 (MBOAT7)-Driven Lysophosphatidylinositol (LPI) Acylation in Adipocytes Contributes to Systemic Glucose Homeostasis

This study shows that MBOAT7 in adipocytes regulates PI homeostasis and contributes to hyperinsulinemia and systemic insulin resistance in mice.

TNF signaling is required for castration-induced vascular damage preceding prostate cancer regression

This study shows TNF signaling is required for castration-induced vascular damage in prostate cancer, which contributes to tumor regression.

Glucocorticoid signaling delays castration-induced regression in murine models of prostate cancer

This study shows that glucocorticoid signaling delays castration-induced regression in murine prostate cancer models by maintaining tumor proliferation through GR activation, which can be blocked by the GR antagonist relacorilant.

Plant-based biosensors for detecting CRISPR-mediated genome engineering

This study develops plant-based biosensors to detect CRISPR/Cas tools in real-time, demonstrating their effectiveness in detecting various CRISPR functions in multiple plant species.

Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility

This study shows that MHC-I autoimmune alleles are associated with reduced melanoma risk and later diagnosis age, independent of existing polygenic risk scores.

Structural and mechanistic insight into CRISPR-Cas9 inhibition by anti-CRISPR protein AcrIIC4

This study investigates how AcrIIC4 inhibits CRISPR-Cas9 by binding to its Recognition Domain and blocking DNA cleavage through conformational changes.

All-Flesh Tomato Regulated by Reduced Dosage of AFF Provides New Insights into Berry Fruit Evolution

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

An Engineered Genetic Circuit for Lactose Intolerance Alleviation Coupled with Gut Microbiota Recovery

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

Long-term survival of salmon-attached SARS-CoV-2 at 4 degree as a potential source of transmission in seafood markets

This study shows that SARS-CoV-2 attached to salmon can remain infectious for over a week at 4°C, indicating a potential transmission risk in seafood markets.

Machine learning reveals time-varying microbial predictors with complex effects on glucose regulation

This study uses machine learning to identify gut microbiome predictors of glucose regulation and T2D risk using longitudinal data from a Finnish cohort.

Actinobacillus utilizes a binding-protein dependent ABC transporter to acquire Vitamin B6

The paper identifies a Vitamin B6 uptake system in Actinobacillus using a binding-protein dependent ABC transporter, validated through structural and biochemical methods.

Targeted delivery of acid alpha-glucosidase corrects skeletal muscle phenotypes in Pompe disease mice

This study demonstrates that targeted enzyme replacement therapy using antibody-enzyme fusion proteins improves skeletal muscle phenotypes in Pompe disease mice compared to standard enzyme replacement therapy.

Effects of rhein on bile acid homeostasis in rats

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

Deep learning reveals cancer metastasis and therapeutic antibody targeting in whole body

This paper introduces DeepMACT, a pipeline for automated detection of cancer metastases and therapeutic antibody targeting in whole-body mouse models using deep learning and enhanced imaging.

Role of the Fourth Transmembrane Segment in TRAAK Channel Mechanosensitivity

This study identifies the role of the fourth transmembrane domain in TRAAK channel mechanosensitivity through chimeric mutations and functional analysis.

Processing of grassland soil C-N compounds into soluble and volatile molecules is depth stratified and mediated by genomically novel bacteria and archaea

The paper links genomically novel soil microbes to depth-stratified carbon and nitrogen cycling by analyzing metagenomic and proteomic data from grassland soils.

Dimethylarsenic acid (DMA) accumulation positively correlates with realgar-induced subchronic toxicity in rats

This study shows that dimethylarsenic acid (DMA) accumulation correlates with realgar-induced toxicity in rats, with liver and kidney damage reversing after drug withdrawal.