OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases
G. Sturm, K. R. Karan, A. Monzel, B. S. Santhanham, T. Taivassalo, C. Bris, S. A. Duplaga, M. Cross, A. Towheed, A. Higgins-Chen, M. J. McManus, A. Cardenas, J. Lin, E. S. Epel, S. Rahman, , M. Picard
The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.
bioRxiv · Nov 29, 2021Cell Biology