Author

A. Higgins-Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:DNA methylation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Approach:statistical model· 2

Frequent Co-Authors

M. Levine· 3 shared B. A. Kaufman· 2 shared C. Bris· 2 shared E. S. Epel· 2 shared G. Lenaers· 2 shared G. Sturm· 2 shared J. Lin· 2 shared K. R. Karan· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

M. Levine

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging

N. Bobba-Alves, G. Sturm, J. Lin, S. A. Ware, K. R. Karan, A. S. Monzel, C. Bris, V. Procaccio, G. Lenaers, A. Higgins-Chen, M. Levine, S. Horvath, B. S. Santhanam, B. A. Kaufman, M. Hirano, , M. Picard

The paper shows chronic glucocorticoid exposure increases cellular energy expenditure and accelerates aging in human fibroblasts.

Psychoneuroendocrinology · Sep 1, 2023Peer-reviewedCell Biology

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

G. Sturm, K. R. Karan, A. Monzel, B. S. Santhanham, T. Taivassalo, C. Bris, S. A. Duplaga, M. Cross, A. Towheed, A. Higgins-Chen, M. J. McManus, A. Cardenas, J. Lin, E. S. Epel, S. Rahman, , M. Picard

The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.

bioRxiv · Nov 29, 2021Cell Biology

Cellular aging in vitro recapitulates multi-tissue epigenetic aging in vivo

C. Minteer, M. Morselli, M. Meer, J. Cao, A. Higgins-Chen, S. Lang, M. Pellegrini, Q. Yan, M. Levine

This study shows that in vitro cellular aging models can reflect multi-tissue epigenetic aging in vivo, using DNAmCULTURE as a measure that tracks aging across tissues and responds to interventions.

bioRxiv · Sep 2, 2020 · PreprintPathology