Author

G. Sturm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:statistical model· 6 Research Focus:cell type annotation· 5 Assay:DNA methylation· 5 Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:metabolism & bioenergetics· 4 Research Focus:chromatin & epigenetic regulation· 3

Frequent Co-Authors

M. Picard· 6 shared M. Hirano· 5 shared S. Horvath· 4 shared A. Cardenas· 3 shared B. A. Kaufman· 3 shared C. Bris· 3 shared J. Lin· 3 shared K. R. Karan· 3 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersCell Biology

M. Picard

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Accelerated physiology and increased energy expenditure in animals and humans with mitochondrial defects: A meta-analysis

A. J. Sercel, G. Sturm, E. D. Shaulson, D. Gallagher, M.-P. St-Onge, C. P. Kempes, H. Pontzer, M. Hirano, M. Picard

This study meta-analyzes energy expenditure in mitochondrial defect models, finding elevated energy costs in 51% of animal studies and similar trends in humans, suggesting hypermetabolism.

bioRxiv · Sep 9, 2023 · PreprintCell Biology

Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging

N. Bobba-Alves, G. Sturm, J. Lin, S. A. Ware, K. R. Karan, A. S. Monzel, C. Bris, V. Procaccio, G. Lenaers, A. Higgins-Chen, M. Levine, S. Horvath, B. S. Santhanam, B. A. Kaufman, M. Hirano, , M. Picard

The paper shows chronic glucocorticoid exposure increases cellular energy expenditure and accelerates aging in human fibroblasts.

Psychoneuroendocrinology · Sep 1, 2023Peer-reviewedCell Biology

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

C. Plattner, G. Lamberti, P. Blattmann, A. Kirchmair, D. Rieder, Z. Loncova, G. Sturm, S. Scheidl, M. E. Ijsselsteijn, G. Fotakis, A. Noureen, R. Lisandrelli, N. Boeck, N. Nemati, A. Krogsdam, , Z. Trajanoski

The paper uses patient-derived organoids and phosphoproteomics to study signaling crosstalk in colorectal cancer and identify off-target effects of kinase inhibitors.

bioRxiv · Sep 16, 2022Cancer Biology

Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cells

G. Sturm, N. Bobba-Alves, R. A. Tumasian, J. Michelson, L. Ferrucci, C. P. Kempes, M. Picard

This study shows that human cells age faster when they consume energy more rapidly, linking metabolic rate to molecular aging markers across the lifespan.

bioRxiv · May 10, 2022 · PreprintCell Biology

High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer

S. Salcher, G. Sturm, L. Horvath, G. Untergasser, G. Fotakis, E. Panizzolo, A. Martowicz, G. Pall, G. Gamerith, M. Sykora, F. Augustin, K. Schmitz, F. Finotello, D. Rieder, S. Sopper, , Z. Trajanoski

The paper integrates single-cell data to create a high-resolution atlas of NSCLC tumor microenvironments, revealing immune cell diversity, neutrophil plasticity, and associations with treatment outcomes.

bioRxiv · May 9, 2022Cancer Biology

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

G. Sturm, K. R. Karan, A. Monzel, B. S. Santhanham, T. Taivassalo, C. Bris, S. A. Duplaga, M. Cross, A. Towheed, A. Higgins-Chen, M. J. McManus, A. Cardenas, J. Lin, E. S. Epel, S. Rahman, , M. Picard

The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.

bioRxiv · Nov 29, 2021Cell Biology

A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations

G. Sturm, A. S. Monzel, K. R. Karan, J. Michelson, S. A. Ware, A. Cardenas, J. Lin, C. Bris, B. Santhanam, M. P. Murphy, M. E. Levine, S. Horvath, D. W. Belsky, S. Wang, V. Procaccio, , M. Picard

The paper presents a longitudinal multi-omics dataset of human fibroblasts with mitochondrial perturbations to study aging mechanisms and bioenergetics.

bioRxiv · Nov 12, 2021Cell Biology

Extracellular riboflavin induces anaerobic biofilm formation in Shewanella oneidensis

M. Edel, G. Sturm, K. Sturm-Richter, M. Wagner, J. Novion Ducassou, Y. Coute, H. Horn, J. Gescher

This study shows that riboflavin acts as a quorum sensing molecule in Shewanella oneidensis, triggering anaerobic biofilm formation at a specific threshold concentration.

bioRxiv · Feb 19, 2021Microbiology

Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured Fibroblasts

G. Sturm, A. Cardenas, M.-A. Bind, S. Horvath, S. Wang, Y. Wang, S. Hagg, M. Hirano, M. Picard

bioRxiv · Apr 10, 2019Cell Biology