S. Rahman

Transcriptomic Insights into the Virulence of Acinetobacter baumannii During Infection: Role of Iron Uptake and Siderophore Production Genes

This study identifies iron uptake and siderophore production genes as key virulence factors in Acinetobacter baumannii using transcriptomic analysis of an infection model.

Haspin kinase binds to a nucleosomal DNA supergroove

The paper reports cryo-EM structures of Haspin kinase bound to a nucleosome, revealing its unique DNA supergroove binding mechanism for phosphorylating H3T3.

An optical aptamer-based cytokine nanosensor detects macrophage activation by bacterial toxins

This paper develops an optical cytokine nanosensor using SWCNT and IL-6-specific aptamers to detect macrophage activation by bacterial toxins with high sensitivity and rapid response.

Designing a Novel 3D Scaffold for Multiepitope Vaccine Development: Engineering Ag85a Protein for Enhanced Stability and Antigenicity

This study designs a scaffold-based multiepitope vaccine against tuberculosis by engineering the Ag85A protein to enhance stability and antigenicity through computational methods.

Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch

This study reveals that H2BK120ub blocks the nucleosome acidic patch, preventing protein binding, while H2AK119ub does not, highlighting distinct roles of these ubiquitinations in chromatin regulation.

Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia

The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.

Comprehensive Network and Structural Analysis of Bovine Papillomavirus, Squamous Cell Carcinoma Markers, and Elucidation of Efficacy Mechanisms of Phytochemicals from Thuja Occidentalis

This study identifies BPV E1 protein interactions with bEGFR and evaluates thuja phytochemicals' efficacy against BPV and squamous cell carcinoma networks.

Noninvasive Injectable Optical Nanosensor-Hydrogel Hybrids Detect Doxorubicin in Living Mice

This paper develops a noninvasive optical nanosensor-hydrogel hybrid that detects doxorubicin in live mice, showing stability and functionality over several weeks.

Putative staphylococcal enterotoxin possesses two common structural motifs for MHC-II binding

This study characterizes a putative staphylococcal enterotoxin, SEl26, showing its structural similarity to conventional SAgs and its ability to bind MHC-II and modulate cytokines.

Targeting staphylococcal cell-wall biosynthesis protein FemX through steered molecular dynamics and drug-repurposing approach

This study repurposes FDA-approved drugs against S. aureus by analyzing their binding to FemX using SMD and shows Lumacaftor has higher affinity and lower toxicity.

Engineering 3D neuronal networks with directional endogenous neuronal plasticity pathways

This study creates 3D neuronal tissue mimics with directional firing by programming optogenetic neurons to exhibit spike-timing dependent plasticity.

Stability and heterogeneity in the anti-microbiota reactivity of human milk-derived Immunoglobulin A

This study examines the reactivity of breast milk-derived IgA against the infant microbiota, finding inter-donor heterogeneity and intra-donor stability in anti-bacterial IgA responses.

The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module

This study shows the SWIRM domain of Ada2 tethers the HAT module to SAGA, modulating its deubiquitinating activity.

Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter

This paper investigates the conformational dynamics of the pH-dependent APC antiporter GadC using DEER spectroscopy and AlphaFold2 models, revealing acid-induced structural changes and substrate-specific dynamics.

Distinct cohorts of Aspergillus fumigatus transcription factors are required for epithelial damage occurring via contact- or soluble effector-mediated mechanisms

This study identifies distinct transcription factor cohorts required for early and late phases of epithelial damage caused by Aspergillus fumigatus.

Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome

The paper determines structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosomes using cryo-EM and mass spectrometry-crosslinking, revealing multiple states and the role of ubiquitin in complex assembly.

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.

Finding Druggable Sites in Proteins using TACTICS

TACTICS identifies druggable sites in proteins using molecular dynamics data, clustering, random forest, and fragment docking, predicting novel binding sites in SARS-CoV-2 and Yersinia pestis proteins.

Detection of 'relict' western lineage of citrus tristeza virus virulent genotype in declining Arunachal Wakro orange

The paper identifies a relict western lineage of citrus tristeza virus virulent genotype VT in declining Arunachal Wakro orange orchards, distinct from other Indian and neighboring CTV sequences.

Salt tolerance QTL derived from the Bangladeshi landrace Horkuch

The paper identifies salt tolerance QTL in rice using a reciprocal mapping population and highlights cytoplasm-nuclear interactions and trait co-localization.

Genomic characterization of Vibrio parahaemolyticus from Pacific white shrimp and rearing water in Malaysia reveals novel sequence types and structural variation in genomic regions containing the Photorhabdus insect-related (Pir) toxin-like genes