Enhancing Cytoplasmic Expression of Exogenous mRNA through Dynamic Mechanical Stimulation
J. Chen, A. Patel, M. Mir, M. Hudock, M. Pinezich, B. Guenthart, M. Bacchetta, G. Vunjak-Novakovic, J. Kim
This study uses mechanical oscillation to enhance endosomal escape of mRNA delivered by lipid nanoparticles, improving transfection efficiency without harming cell viability or organelle integrity.
bioRxiv · Jun 19, 2024Bioengineering