B. Heit

MERTK Coordinates Efferocytosis by Regulating Integrin Localization and Activation

This study identifies a MERTK-integrin signaling pathway that coordinates efferocytosis by regulating integrin localization and activation.

SARS-CoV-2 NSP5 Antagonizes MHC II Expression by Subverting Histone Deacetylase 2

This paper identifies how SARS-CoV-2 NSP5 suppresses MHC II expression by delivering HDAC2 to IRF3 at the CIITA promoter, leading to reduced CIITA and MHC II levels.

Customizable Live-Cell Imaging Chambers for Multimodal and Multiplex Fluorescence Microscopy.

This paper introduces 3D-printed live-cell imaging chambers compatible with multiple microscopy modalities, demonstrating their use in various experimental setups.

GATA2 Expression by Intima-Infiltrating Macrophages Drives Early Atheroma Formation

The paper identifies GATA2 overexpression in early-stage atherosclerotic macrophages as a driver of functional defects linked to atheroma formation.

PACS-1 and Adaptor Protein-1 Mediate ACTH Trafficking to the Regulated Secretory Pathway

This study identifies PACS-1 and AP-1 as essential for directing POMC to DCSGs, as their knockdown prevents POMC from being trafficked to these granules.

Soluble CD93 is an Apoptotic Cell Opsonin Recognized by the αxβ2 Integrin

This study identifies soluble CD93 as an opsonin recognized by αxβ2 integrin for efferocytosis, showing membrane-bound CD93 lacks efferocytic activity.

Membrane Diffusion Occurs by a Continuous-Time Random Walk Sustained by Vesicular Trafficking

This study shows that membrane diffusion of CD93 follows a continuous-time random walk sustained by vesicular trafficking, with proteins transitioning between free diffusion and corralled states.