N. Sharma

Discovering Symbolic Cognitive Models from Human and Animal Behavior

LLM-driven evolutionary program synthesis (CogFunSearch) discovers interpretable Python cognitive models that predict bandit-task choices of humans, rats and fruit flies better than leading hand-designed models.

Graph-structured populations elucidate the role of deleterious mutations in long-term evolution

The paper investigates how spatial structure affects evolutionary outcomes by identifying amplifier and suppressor graphs for mutant fixation and their impact on long-term fitness.

A general approach to reduce off-target radioactivity in vivo via Tetrazine-Knock-Out (TKO)

This paper develops a method to rapidly clear radioactivity from blood using a tetrazine-knock-out (TKO) approach, improving imaging contrast and reducing radiation exposure.

Cytosolic Class I J-domain proteins aid mitochondrial protein import and influence homeostasis in Arabidopsis thaliana.

This study identifies two cytosolic Class I J-domain proteins in Arabidopsis thaliana that facilitate mitochondrial protein import and homeostasis by interacting with outer mitochondrial receptors.

Evolutionary origin of synovial joints

This study identifies synovial joints in elasmobranchs but not cyclostomes, suggesting their origin in the common ancestor of jawed vertebrates.

Inflammatory Cytokines Can Induce Synthesis Of Type-I Interferon

The paper shows inflammatory cytokines like TNF-α and IL-1β can induce IFN-β through RIG-I signaling pathway activation via PACT and MAPK/p38 phosphorylation.

Clustered Regularly Interspaced Short Palindromic Repeats-Cas system regulates Salmonella virulence

This study shows that the CRISPR-Cas system in Salmonella enhances virulence by regulating virulence factor expression.

Spatial organization of collective food distribution in a paper wasp society

The paper studies food distribution in paper wasp colonies, finding that feeding routes are optimized based on food load and that larvae near the nest center are fed more frequently.

The minimum intervention principle of optimal control relates the uncontrolled manifold to muscle synergies

This study links muscle synergies to task mechanics using biomechanical models and shows variability in muscle activities aligns with task-irrelevant directions.

Deciphering the orthorhombic crystal structure of a novel NEIL1 nanobody with pseudo-merohedral twinning

The paper determines the orthorhombic crystal structure of a NEIL1-specific nanobody at 2.1 Å resolution, revealing pseudo-merohedral twinning and resolving over 96% of residues.

Disparate requirements for RAD54L in replication fork reversal

This study identifies RAD54L's distinct roles in two RAD51-mediated replication fork reversal pathways, showing it is critical in the HLTF/SMARCAL1 pathway but not in the FBH1 pathway.

Emergence of resistance to succinate dehydrogenase inhibitor fungicides in Pyrenophora teres f. teres and P. teres f. maculata in Australia

This paper identifies novel mutations in the Sdh complex genes of Pyrenophora teres isolates in Australia that confer resistance to SDHI fungicides, with specific mutations linked to reduced in vitro sensitivity.

Self-loops in Evolutionary Graph Theory: Friends or Foes?

The paper examines the impact of self-loops on evolutionary dynamics in structured populations, showing they are beneficial at low mutation rates but detrimental at intermediate and high rates.

SiHDA9 interacts with SiHAT3.1 and SiHDA19 to repress dehydration responses through H3K9 deacetylation in foxtail millet

The paper identifies SiHDA9's role in repressing drought responses by deacetylating H3K9 on target genes in foxtail millet through interaction with SiHAT3.1 and SiHDA19.

Role of maternal, fetal and placental histopathology factors in the pathogenesis of retinopathy of prematurity.

The paper investigates maternal, fetal, and placental factors predicting retinopathy of prematurity risk in preterm infants using histopathology and molecular analysis.

Impact of urbanization on the taxonomic and functional diversity of spider assemblages in Guwahati City, Assam, India

This study examines how urbanization affects spider taxonomic and functional diversity in Guwahati, finding lower diversity and altered functional traits in urban areas compared to forests.

Niche partitioning and coexistence of sympatric macaques in a fragmented habitat of the Upper Brahmaputra Valley, northeastern India

This study examines how three sympatric macaque species partition resources in a fragmented rainforest, finding that spatial and dietary niche differentiation enables their coexistence.

Single-molecule visualization of stalled replication-fork rescue by the Escherichia coli Rep helicase

This study visualizes how the Escherichia coli Rep helicase rescues stalled replication forks by removing roadblocks, showing replication restart is the rate-limiting step.

Categorising update mechanisms for graph-structured metapopulations

This paper classifies update mechanisms for graph-structured metapopulations to identify commonalities and research gaps.

Ancestral SARS-CoV-2 driven antibody repertoire diversity in an unvaccinated individual correlates with expanded neutralization breadth

The paper examines antibody diversity in an unvaccinated SARS-CoV-2 infected individual, finding that post-vaccination neutralization breadth against Omicron variants is comparable to vaccinated individuals and breakthrough infections.

Longitudinal characterization of circulating neutrophils uncovers distinct phenotypes associated with disease severity in hospitalized COVID-19 patients

This study identifies distinct neutrophil phenotypes linked to disease severity in hospitalized COVID-19 patients using longitudinal data and multi-omics analyses.

Genomewide basis for nitrogen use efficiency in contrasting genotypes of rice

This study compares transcriptomes of rice genotypes with contrasting nitrogen use efficiency under urea treatment, identifying common and specific gene expression patterns and their association with agronomic performance.

Do amplifiers of selection maximise average fitness?

The paper investigates whether amplifiers of selection maximize population mean fitness in the steady-state by analyzing the impact of different graph structures on mutant fixation probabilities and fitness outcomes.

The aggregation potential of Zika virus proteome

This study identifies aggregation-prone regions in the Zika virus proteome using computational tools and experimental validation, showing several viral proteins can form amyloid-like fibrils.

The CRISPR-Cas System differentially regulates surface-attached and pellicle-biofilm in Salmonella enterica serovar Typhimurium

This study shows the CRISPR-Cas system in Salmonella Typhimurium promotes surface-biofilm while inhibiting pellicle-biofilm through gene regulation of flagellar, curli, and cellulose pathways.

Polyfunctional IL-17A+ MAIT cells are expanded in the peripheral blood of patients with HLA-B27+ axial spondyloarthritis

This study identifies an expansion of polyfunctional IL-17A+ MAIT cells in HLA-B27+ axSpA patients, linking intestinal inflammation to axial spondyloarthritis pathogenesis.

Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants by Modular, Tetravalent, Bi-paratopic Antibodies

This study develops a tetravalent antibody format that neutralizes SARS-CoV-2 variants with high potency and breadth, surpassing conventional bivalent antibodies.

RAD51AP1 and RAD54 underpin two distinct RAD51-dependent routes of DNA damage repair via homologous recombination

This study identifies RAD51AP1 and RAD54 as two distinct RAD51-dependent HR sub-pathways, showing their combined inactivation enhances cancer cell sensitivity to DNA damage agents.

Multi-environment QTL analysis delineates a major locus associated with homoeologous exchanges for water-use efficiency and seed yield in allopolyploid Brassica napus

This study identifies a major QTL on chromosome A09 associated with water-use efficiency and seed yield in Brassica napus, linked to homoeologous exchanges and gene expression differences.

Effect of prophylactic use of intra-nasal oil formulations in the hamster model of Covid-19

The paper evaluates two intra-nasal oil formulations in a hamster model of SARS-CoV-2 infection, finding that Anu oil reduces viral load, body weight loss, and lung pathology compared to the control.