C. Jung

Leaf and shoot apical meristem transcriptomes of quinoa (Chenopodium quinoa Willd.) in response to photoperiod and plant development

This study identifies differentially expressed genes in quinoa leaf and shoot apical meristems under varying photoperiod and developmental conditions, highlighting potential regulators of flowering time.

Inhibition of proline-rich-tyrosine kinase 2 restores cardioprotection by remote ischemic preconditioning in type 2 diabetes mellitus

This study shows that inhibiting Pyk2 restores cardioprotection lost in diabetes through improved endothelial function and eNOS activity during remote ischemic preconditioning.

SARS-CoV-2 NSP5 Antagonizes MHC II Expression by Subverting Histone Deacetylase 2

This paper identifies how SARS-CoV-2 NSP5 suppresses MHC II expression by delivering HDAC2 to IRF3 at the CIITA promoter, leading to reduced CIITA and MHC II levels.

Reduced glucosinolate content in oilseed rape (Brassica napus L.) by random mutagenesis of BnMYB28 and BnCYP79F1 genes

This study reduces glucosinolate content in rapeseed by knocking out BnMYB28 and BnCYP79F1 genes, resulting in significantly lower aliphatic GSL levels in seeds.

Tumor necrosis factor is a necroptosis-associated alarmin

This study identifies TNF as a necroptosis-associated alarmin by showing that necroptosis promotes TNF translation and release through ADAM protease activation.

An interaction between betaprime-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling

This study identifies the interaction between betaprime-COP and Glo3, an ArfGAP, showing it is essential for post-Golgi cargo recycling in yeast.

Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

This study examines how specific mutations in the SARS-CoV-2 Omicron Spike protein affect infectivity, processing, and neutralization by antibodies.

Massively Parallel Selection of NanoCluster Beacons

The paper develops a high-throughput method to screen and design multicolor NanoCluster Beacons using NGS chips and machine learning.

An increase in surface hydrophobicity mediates chaperone activity in N-chlorinated proteins

This study identifies specific chlorinated residues in RidA that are critical for its chaperone activity under oxidative stress.

Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2

The paper shows that a single amino acid mutation in the Spike protein of bat coronavirus RaTG13 enables it to use human ACE2 for infection.

Expansion of the prime editing modality with Cas9 from Francisella novicida

This study expands prime editing by linking reverse transcriptase to FnCas9(H969A) nickase, enabling more precise and extended target gene modifications.

Natural Cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling

The paper identifies a Cystatin C fragment that inhibits GPR15-mediated HIV and SIV infection without affecting GPR15L signaling.

Validation of suitable genes for normalization of diurnal gene expression studies in Chenopodium quinoa

This study validates suitable reference genes for normalizing diurnal gene expression in quinoa using statistical algorithms and simulation-based validation.

Nod2 protects remote small intestinal sites in case of colonic inflammation.

The paper shows that NOD2 prevents small intestinal inflammation in areas remote from colonic injury in mice.

Supercharging enables organized assembly of synthetic biomolecules

The paper describes a method to assemble synthetic protein oligomers and higher-order structures using supercharged variants of fluorescent proteins, resulting in novel biomaterials.