Characterizing the conformational free-energy landscape of RNA stem-loops using single-molecule field-effect transistors
S. S. Jang, S. Dubnik, J. Hon, B. Hellenkamp, D. G. Lynall, K. L. Shepard, C. Nuckolls, R. L. Gonzalez
This study uses single-molecule field-effect transistors to analyze the conformational free-energy landscape of RNA stem-loops, revealing a rugged landscape with unfolding timescales of 1-200 ms.
bioRxiv · Jan 13, 2022Biophysics