S. Wolf

Longitudinal sequencing reveals polygenic andepistatic nature of genomic response to selection

This study uses longitudinal sequencing in Drosophila to show that genomic response to selection involves both polygenic shifts and epistatic interactions, with DEGs enriched for selected SNPs.

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

This study identifies molecular vulnerabilities in colorectal cancer by analyzing MSI and MSS tumors, revealing distinct signaling pathways and potential therapeutic targets.

A RALF-Brassinosteroid morpho-signaling circuit regulates Arabidopsis hypocotyl cell shape

This paper identifies a RALF-Brassinosteroid signaling circuit that regulates Arabidopsis hypocotyl cell shape by linking cell wall status to BR signaling through RALF23.

Phosphorylation and ubiquitination independent endocytosis of BRI1

This study shows that a BR-binding-deficient BRI1 mutant is internalized similarly to wild-type BRI1, suggesting parallel endocytic routes and non-canonical functions.

Edge-based growth control in Arabidopsis involves two cell wall-associated Receptor-Like Proteins

The paper identifies two cell wall-associated Receptor-Like Proteins, RLP4 and RLP4-L1, that control directional growth in Arabidopsis by monitoring cell wall status at cell edges.

Wolbachia interacts with the microbiome to shape fitness-associated traits during seasonal adaptation in Drosophila melanogaster

This study shows Wolbachia limits microbial diversity and interacts with the microbiome to influence fitness traits in Drosophila during seasonal adaptation.

Discrimination of edge orientation by bumblebees

This study shows bumblebees can discriminate 7-degree angled edges better than honeybees, suggesting superior angular resolution and potential for complex visual processing.

Temporal control of the integrated stress response by a stochastic molecular switch

The paper identifies a stochastic molecular switch controlling the integrated stress response through cooperative activation of PKR, ultrasensitive eIF2 phosphorylation, and negative feedback via GADD34.

The regeneration factors ERF114 and ERF115 act as transducers of mechanical cues to developmental pathways

This study shows that ERF114 and ERF115 mediate mechanical cues to switch between developmental and regenerative processes in plants.

Cooperative protein allosteric transition mediated by a fluctuating transmission network

The paper studies cooperative protein allosteric transitions in T4 lysozyme, identifying a fluctuating transmission network in the hinge region that drives global conformational changes.

Phosphorylation-dependent routing of RLP44 towards brassinosteroid or phytosulfokine signalling

This study shows that phosphorylation of RLP44's C-terminal tail directs its localization to either brassinosteroid or phytosulfokine signalling pathways.

Optimal BR signalling is required for adequate cell wall orientation in the Arabidopsis root meristem

This study shows that optimal brassinosteroid (BR) signaling is necessary for proper cell wall orientation in the Arabidopsis root meristem, with defects linked to altered cortical division zone localization.

ARGONAUTE10 is required for cell fate specification and the control of formative cell divisions in the Arabidopsis root meristem

This study shows ARGONAUTE10 maintains miRNA gradients to regulate cell fate and division in Arabidopsis root meristems, preventing ectopic xylem formation.

Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera

The paper develops a semi-quantitative microscopy-based assay to detect SARS-CoV-2 specific antibodies in human sera, providing a sensitive and specific method for serological analysis.

Cell wall damage attenuates root hair cell patterning and tissue morphogenesis mediated by the Arabidopsis receptor kinase STRUBBELIG.

The paper shows that cell wall damage disrupts root hair patterning and floral morphogenesis via attenuation of SUB signaling in Arabidopsis.

Three-fluorophore FRET enables the analysis of ternary protein association in living plant cells

The paper uses three-fluorophore FRET and FLIM to show BRI1, BAK1, and RLP44 form a ternary complex in plant plasma membrane nanodomains, distinct from FLS2/BAK1 complexes.

Cell-to-cell spread inhibiting antibodies constitute a correlate of protection against Herpes Simplex Virus Type 1 reactivations

The paper identifies cell-to-cell spread inhibiting antibodies as a correlate of protection against HSV-1 reactivations by screening plasma samples and correlating antibody levels with reactivation frequency.

Hierarchical coupling between ATP hydrolysis and Hsp90's client binding site

The paper identifies a hierarchical mechanism by which ATP hydrolysis in Hsp90 influences its substrate binding site through structural asymmetry and allosteric dynamics.

From behavior to circuit modeling of light-seeking navigation in zebrafish larvae

The paper develops a Markov-chain model of light-seeking navigation in zebrafish larvae and maps it onto a neuronal model of the ARTR circuit to capture navigation statistics.

Distinct and overlapping functions of Miscanthus sinensis MYB transcription factors SCM1 and MYB103 in lignin biosynthesis

This study characterizes two MYB transcription factors in Miscanthus that influence lignin biosynthesis and shows their distinct and overlapping transcriptional impacts compared to a master regulator.

A novel mutant allele uncouples brassinosteroid-dependent and independent functions of BRI1

A novel BRI1 mutant uncouples BR signaling and RLP44 function, revealing distinct roles of BRI1 in vascular development and hormone response.

Enemy release mitigates inbreeding depression in native and invasive Silene latifolia populations: experimental insight into the role of inbreeding x environment interactions in invasion success

Marine mammals and sea turtles listed under the U.S. Endangered Species Act are recovering

The paper analyzes population trends of ESA-listed marine mammals and sea turtles, finding that 78% of marine mammals and 78% of sea turtles showed significant population increases after listing.