Author

J. Hon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:variational autoencoder· 1

Frequent Co-Authors

R. L. Gonzalez· 2 shared B. Hellenkamp· 1 shared C. Nuckolls· 1 shared D. G. Lynall· 1 shared K. L. Shepard· 1 shared M. Zhou· 1 shared R. Fang· 1 shared S. Dubnik· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

R. L. Gonzalez

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3 papers

Recent·Most cited

Characterizing the conformational free-energy landscape of RNA stem-loops using single-molecule field-effect transistors

S. S. Jang, S. Dubnik, J. Hon, B. Hellenkamp, D. G. Lynall, K. L. Shepard, C. Nuckolls, R. L. Gonzalez

This study uses single-molecule field-effect transistors to analyze the conformational free-energy landscape of RNA stem-loops, revealing a rugged landscape with unfolding timescales of 1-200 ms.

bioRxiv · Jan 13, 2022Biophysics

An Empirical Energy Landscape Reveals Mechanism of Proteasome in Polypeptide Translocation

R. Fang, J. Hon, M. Zhou, Y. Lu

The paper develops a free-energy landscape model of the proteasome ATPase complex to reveal how ATP hydrolysis drives substrate translocation through cooperative subunit movements.

bioRxiv · Jun 21, 2021Biophysics

Bayesian-estimated hierarchical HMMs enable robust analysis of single-molecule kinetic heterogeneity

J. Hon, R. L. Gonzalez

This paper introduces hFRET, a computational tool using Bayesian hierarchical HMMs to analyze single-molecule kinetic heterogeneity, demonstrating its effectiveness with simulated and experimental data.

bioRxiv · Aug 30, 2018Biophysics