A HEV ORF2 protein-mediated mechanism of hepatitis E associated kidney disease.
B. Helmchen, A.-L. Leblond, D. Lenggenhager, J. Jetzer, M. Ankavay, F. Helmchen, H. Yurtsever, R. Parrotta, M. E. Healy, A. Poeschel, E. Markkanen, N. Semmo, M. Ferrie, L. Cocquerel, H. Seeger, , A. Weber
This study identifies HEV ORF2 protein as a cause of glomerulonephritis in hepatitis E patients through immune complex deposition, without detectable viral particles or RNA.
bioRxiv · Sep 14, 2023 · PreprintPathology