A. Weber

A HEV ORF2 protein-mediated mechanism of hepatitis E associated kidney disease.

This study identifies HEV ORF2 protein as a cause of glomerulonephritis in hepatitis E patients through immune complex deposition, without detectable viral particles or RNA.

Application of self-organizing maps to AFM-based viscoelastic characterization of breast cancer cell mechanics

This study uses self-organizing maps to classify AFM-based mechanical data from breast cancer cells treated with estrogen and resveratrol, showing changes in stiffness and viscosity.

Light-dependent Control of Bacterial Expression at the mRNA Level

This paper develops optogenetic systems using the PAL photoreceptor to control bacterial gene expression at the mRNA level through light-responsive RNA aptamers.

Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice

This study shows that lactational exposure to Triclosan in mice causes fatty liver disease by disrupting metabolic pathways involving PERK-eIF2-ATF4-PPAR.

Natural and human-mediated drivers of microevolution in Neotropical palms: a historical genomics approach

This study explores genomic diversity in Neotropical palms to understand natural and human-mediated microevolution in Amazonia, revealing insights into climate adaptation and pre-Columbian domestication.

miRNA mediated downregulation of non-muscle Cyclase associated protein 1 is required for myogenic differentiation

This study shows that miRNA-mediated downregulation of Cap1 is essential for myogenic differentiation by regulating actin dynamics and myoblast fusion.

Rapid, multianalyte detection of opioid metabolites in wastewater

This paper presents an aptamer-based graphene field effect transistor platform for rapid, reliable, and cost-effective detection of three opioid metabolites in wastewater.

Nuclei are mobile processors enabling specialization in a gigantic single-celled syncytium

This study investigates gene expression heterogeneity in the multinucleated slime mold Physarum polycephalum, showing region-specific transcriptional responses and nuclear specialization without cellular compartmentalization.

NRF1 Association with AUTS2-Polycomb Mediates Specific Gene Activation in the Brain

The paper identifies NRF1's role in PRC1.3 recruitment to chromatin and shows AUTS2 mutations disrupt gene regulation and motor neuron differentiation.

A SARS-CoV-2 spike binding DNA aptamer that inhibits pseudovirus infection in vitro by an RBD independent mechanism

This study identifies an aptamer that inhibits SARS-CoV-2 pseudovirus infection without targeting the RBD or ACE2 interaction.

Inhibiting coronavirus replication in cultured cells by chemical ER stress

This study shows that thapsigargin inhibits coronavirus replication by modulating ER stress and quality control pathways in cultured cells.

Detection of a multi-disease biomarker in Salivawith Graphene Field Effect Transistors

This paper develops a label-free biosensor using graphene field effect transistors to detect CA1 in saliva, achieving high sensitivity and clinical relevance.

TRAF6 controls spinogenesis instructing synapse density and neuronal activity through binding neuroplastin

This study identifies TRAF6 as a regulator of spinogenesis through its interaction with neuroplastin, affecting synapse density and neuronal activity in hippocampal neurons.

Transcriptome dynamics in developing leaves from C3 and C4 Flaveria species reveal determinants of Kranz anatomy

The paper compares transcriptome dynamics in developing leaves of C3 and C4 Flaveria species to identify molecular determinants of Kranz anatomy, finding auxin homeostasis is critical for high vein density in C4 leaves.

Arabidopsis species deploy distinct strategies to cope with drought stress

This study compares drought stress responses in three Arabidopsis species, finding distinct survival strategies involving avoidance, tolerance, and recovery mechanisms.

Optimised DNA extraction and library preparation for minute arthropods: application to target enrichment in chalcid wasps used for biocontrol.

The paper optimizes DNA extraction and library preparation for minute arthropods, enabling effective target enrichment for phylogenetic studies in chalcid wasps.

Biochemical mechanisms driving rapid fluxes in C4 photosynthesis

The paper investigates biochemical mechanisms enabling rapid fluxes in C4 photosynthesis and their implications for plant growth and carbon fixation efficiency.

Natural variation in stomata size contributes to the local adaptation of water-use efficiency in Arabidopsis thaliana

This study identifies genetic variation in stomata size and density in Arabidopsis thaliana and links it to water-use efficiency through carbon isotope discrimination.

The proto CpG island methylator phenotype of sessile serrated adenoma/polyps

This paper identifies distinct DNA methylation patterns in sessile serrated adenomas/polyps (SSA/Ps) compared to conventional adenomas, introducing the term 'proto-CIMP' and highlighting their potential as biomarkers.