Author

B. Heras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:E. coli· 3 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

M. Totsika· 3 shared A. E. Whitten· 2 shared J. J. Paxman· 2 shared Y. Hong· 2 shared A. D. Verderosa· 1 shared A. Lo· 1 shared G. C. Martinez Ortiz· 1 shared G. King· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMicrobiology

M. Totsika

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Bacterial suppressor-of-copper-sensitivity (Scs) proteins exhibit diverse thiol-disulfide oxidoreductase cellular functions

Y. Hong, J. Qin, L. Mitchell, J. J. Paxman, B. Heras, M. Totsika

This study shows that ScsC proteins, despite structural differences, exhibit both dithiol oxidation and disulfide reduction activity, with oxidase activity dependent on environmental oxidation.

bioRxiv · Feb 7, 2023Microbiology

Fine tuning the mechanism of Antigen 43 self-association to modulate aggregation levels of Escherichia coli pathogens

J. Vo, G. C. Martinez Ortiz, M. Totsika, A. Lo, A. E. Whitten, L. Hor, K. M. Peters, V. Ageorges, N. Caccia, M. Desvaux, M. A. Schembri, J. J. Paxman, B. Heras

The paper investigates the role of Ag43 homologues in bacterial aggregation and biofilm formation, revealing a common trans-association mechanism and how variations in these interactions affect aggregation kinetics.

bioRxiv · Apr 19, 2021 · PreprintBiochemistry

High-throughput cell-based assays for the preclinical development of DsbA inhibitors as antivirulence therapeutics.

A. D. Verderosa, R. Dhouib, Y. Hong, B. Heras, M. Totsika

This paper establishes a high-throughput cell-based assay pipeline for evaluating DsbA inhibitors as antivirulence therapeutics using Escherichia coli and UPEC.

bioRxiv · Mar 3, 2020Microbiology

The atypical thiol-disulfide exchange protein alpha-DsbA2 from Wolbachia pipientis is a homotrimeric disulfide isomerase

P. M. Walden, P. Lakshmanane, M. Halili, B. Heras, G. King, A. E. Whitten, J. L. Martin

This study characterizes the structure and function of DsbA2 from Wolbachia pipientis, revealing it as a homotrimeric disulfide isomerase with distinct activity compared to other DsbA enzymes.

bioRxiv · Sep 11, 2018Biochemistry