L. Mitchell

Broad diversity of human gut bacteria accessible via a traceable strain deposition system

The paper establishes a publicly available collection of 340 human gut bacterial strains, including 29 newly described species, and identifies plasmids and megaplasmids within these isolates.

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

The eIF4A2 negative regulator of mRNA translation promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.

Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis

This study shows that triple-negative breast cancer cells secrete anti-ferroptotic MUFAs and rely on selenoprotein synthesis for metastasis.

Biochemical characterization of mRNA capping enzyme from Faustovirus

This study characterizes a single-subunit RNA capping enzyme from Faustovirus, showing it efficiently generates Cap-0 structures and has advantageous properties for synthetic mRNA manufacturing.

Spatial autocorrelation dimension as a potential determinant for the temporal persistence of human atrial and ventricular fibrillation.

The paper investigates whether the spatial autocorrelation dimension (Di) predicts the time to termination of human atrial and ventricular fibrillation.

Bacterial suppressor-of-copper-sensitivity (Scs) proteins exhibit diverse thiol-disulfide oxidoreductase cellular functions

This study shows that ScsC proteins, despite structural differences, exhibit both dithiol oxidation and disulfide reduction activity, with oxidase activity dependent on environmental oxidation.

N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation

This study investigates how N1-methylpseudouridine and pseudouridine modifications affect mRNA decoding during translation, showing they influence amino acid misincorporation depending on codon position and tRNA context.

Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness

This study identifies how GBM extracellular vesicles containing podocalyxin promote astrocyte hyaluronic acid deposition, enhancing GBM invasiveness.

Shorter constant work rate cycling tests as proxies for longer tests in highly trained cyclists

This study shows that a 2-minute constant work rate cycling test can serve as a proxy for a 4-minute test in highly trained cyclists, as it correlates strongly with longer test outcomes while being less fatiguing.

The C-terminal regions of TRAK proteins contain MIRO-independent mitochondrial outer membrane binding domains

The paper identifies MIRO-independent mitochondrial outer membrane binding domains in TRAK proteins using fluorescence microscopy and kinetic analysis.

Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts

This paper demonstrates the use of iRFP expression in patient-derived glioblastoma cells for non-invasive, quantitative monitoring of tumor growth in vivo.

Renewal theory provides a universal quantitative framework to characterise the continuous regeneration of rotational events in cardiac fibrillation

The paper applies renewal theory to model phase singularity dynamics in cardiac fibrillation across species, finding exponential inter-event time distributions with consistent rate parameters.